LY 344864 hydrochloride

Cat. No. 2451 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective 5-HT_1F agonist

化学名： N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide hydrochloride

纯度： ≥99% (HPLC)

引用文献 (3)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for LY 344864 hydrochloride

LY 344864 hydrochloride is a potent, selective 5-HT_1F receptor agonist (EC₅₀ = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (K_i values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μM for 5-HT_1F, 5-HT_1A, 5-HT_1B, 5-HT_1D, 5-HT_1E, 5-HT_2B, 5-HT_2C, 5-HT_2A and 5-HT₇ receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.

许可信息

Sold under license from Eli Lilly and Company

化合物库 for LY 344864 hydrochloride

LY 344864 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for LY 344864 hydrochloride

分子量	387.88
公式	C₂₁H₂₂N₃OF.HCl
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	1217756-94-9
PubChem ID	56972176
InChI Key	OKUHLSYESBLBCP-PKLMIRHRSA-N
Smiles	Cl[H].CN(C)[C@@H]1CCC2=C(C1)C1=CC(NC(=O)C3=CC=C(F)C=C3)=CC=C1N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for LY 344864 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	19.39	50
	DMSO	38.79	100

制备储备液 for LY 344864 hydrochloride

以下数据基于产品分子量 387.88。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.58 mL	12.89 mL	25.78 mL
5 mM	0.52 mL	2.58 mL	5.16 mL
10 mM	0.26 mL	1.29 mL	2.58 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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产品说明书 for LY 344864 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for LY 344864 hydrochloride

参考文献是支持产品生物活性的出版物。

Ramadan et al (2003) 5-HT_1F receptor agonists in acute migraine treatment: a hypothesis. Cephalalgia 23 776 PMID: 14510923

Goadsby and Classey (2003) Evidence for serotonin (5-HT)_1B, 5-HT_1D and 5-HT_1F receptor inhibitory effects on trigeminal neurons with craniovascular input. Neuroscience 122 491 PMID: 14614913

Lee et al (1997) Characterization of LY344864 as a pharmacological tool to study 5-HT_1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine. Life Science 61 2117

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关键词: LY 344864 hydrochloride, LY 344864 hydrochloride supplier, Potent, selective, 5-HT1F, agonists, Serotonin, Receptors, LY344864, hydrochloride, 2451, Tocris Bioscience

3 篇 LY 344864 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 LY 344864 hydrochloride 的部分引用包括：

Garrett et al (2014) Agonism of the 5-hydroxytryptamine 1F receptor promotes mitochondrial biogenesis and recovery from acute kidney injury. J Pharmacol Exp Ther 350 257 PMID: 24849926

Scholpa et al (2018) 5-HT1F receptor-mediated mitochondrial biogenesis for the treatment of Parkinson's disease. Br J Pharmacol 175 348 PMID: 29057453

Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728

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