LY 393558

Discontinued Product

3350 has been discontinued.

View all 5-HT<sub>1B</sub> Receptors products.
说明: Dual 5-HT1B and 5-HT1D antagonist; also 5-HT re-uptake inhibitor
化学名: 1-[2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-1(2H)-pyridinyl]ethyl]-3,4-dihydro-3-(1-methylethyl)-6-(methylsulfonyl)-1H-2,1,3-benzothiadiazine-2,2-dioxide
纯度: ≥97% (HPLC)
说明书
引用文献
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文献 (2)

生物活性 for LY 393558

LY 393558 is a dual 5-HT1B/1D receptor antagonist (pKB values are 9.05 and 8.98 respectively) and 5-HT re-uptake inhibitor (pIC50 = 8.48). Potently antagonizes terminal autoreceptor activity in vitro and increases extracellular 5-HT levels above those evoked by fluoxetine (Cat. No. 0927) in vivo. Also acts as an antagonist at 5-HT2A and 5-HT2B receptors (pKi values are 7.29 and 7.35 respectively).

技术数据 for LY 393558

分子量 546.68
公式 C26H31FN4O4S2
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 271780-64-4
PubChem ID 10347428
InChI Key QUSLYAPLTMMCFE-UHFFFAOYSA-N
Smiles CC(C)N2S(N(CCN3CC=C(C4=CNC5=C4C=CC(F)=C5)CC3)C1=CC=C(S(=O)(C)=O)C=C1C2)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

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关键词: LY 393558, LY 393558 supplier, LY393558, dual, 5-HT1B, 5-HT1D, 5-HT1B/1D, receptors, antagonists, serotonin, reuptake, uptake, SERT, inhibitors, inhibits, transporters, 5-HT1, 5-Hydroxytryptamine, Receptors, 5-HT, Transporters, 3350, Tocris Bioscience

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该领域的文献

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