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说明： Dual 5-HT1B and 5-HT1D antagonist; also 5-HT re-uptake inhibitor
化学名： 1-[2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-1(2H)-pyridinyl]ethyl]-3,4-dihydro-3-(1-methylethyl)-6-(methylsulfonyl)-1H-2,1,3-benzothiadiazine-2,2-dioxide
纯度： ≥97% (HPLC)
生物活性 for LY 393558
LY 393558 is a dual 5-HT1B/1D receptor antagonist (pKB values are 9.05 and 8.98 respectively) and 5-HT re-uptake inhibitor (pIC50 = 8.48). Potently antagonizes terminal autoreceptor activity in vitro and increases extracellular 5-HT levels above those evoked by fluoxetine (Cat. No. 0927) in vivo. Also acts as an antagonist at 5-HT2A and 5-HT2B receptors (pKi values are 7.29 and 7.35 respectively).
技术数据 for LY 393558
| 分子量 | 546.68 |
| 公式 | C26H31FN4O4S2 |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 271780-64-4 |
| PubChem ID | 10347428 |
| InChI Key | QUSLYAPLTMMCFE-UHFFFAOYSA-N |
| Smiles | CC(C)N2S(N(CCN3CC=C(C4=CNC5=C4C=CC(F)=C5)CC3)C1=CC=C(S(=O)(C)=O)C=C1C2)(=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for LY 393558
参考文献 for LY 393558
参考文献是支持产品生物活性的出版物。
Mitchell et al (2001) LY393558, a 5-hydroxytryptamine reuptake inhibitor and 5-HT1B/1D receptor antagonist: effects on extracellular levels of 5-hydroxytryptamine in the guinea pig and rat. Eur.J.Pharmacol. 432 19 PMID: 11734183
Pullar et al (2001) In vitro activity of LY393558, an inhibitor of the 5-hydroxytryptamine transporter with 5-HT1B/1D/2 receptor antagonist properties. Eur.J.Pharmacol. 432 9 PMID: 11734182
Morecroft et al (2005) Functional interactions between 5-hydroxytryptamine receptors and the serotonin transporter in pulmonary arteries. J.Pharmacol.Exp.Ther. 313 539 PMID: 15659538
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关键词: LY 393558, LY 393558 supplier, LY393558, dual, 5-HT1B, 5-HT1D, 5-HT1B/1D, receptors, antagonists, serotonin, reuptake, uptake, SERT, inhibitors, inhibits, transporters, 5-HT1, 5-Hydroxytryptamine, Receptors, 5-HT, Transporters, 3350, Tocris Bioscience
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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