Lyn peptide inhibitor

Name: Lyn peptide inhibitor
Brand: Tocris Bioscience
SKU: 2265

Cat. No. 2265 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2265 has been discontinued.

View all Cytokine Receptors products.

说明： Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable

说明书

引用文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Lyn peptide inhibitor

Lyn peptide inhibitor is a cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinophil differentiation and survival in vitro. Inhibits airway eosinophilic inflammation in mouse model of asthma.

技术数据 for Lyn peptide inhibitor

分子量	2370.91
公式	C₁₁₅H₁₈₄N₃₀O₂₄
序列	YGYRLRRKWEEKIPNP (Modifications: Tyr-1 = Octadecanoyl-Tyr, Pro-16 = C-terminal amide)
储存	Desiccate at -20°C
CAS Number	222018-18-0
PubChem ID	90001265
InChI Key	MITSVNFZLBORMW-QMGLJYLZSA-N
Smiles	CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Lyn peptide inhibitor

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Lyn peptide inhibitor

参考文献是支持产品生物活性的出版物。

Adachi et al (1999) The mapping of the Lyn kinase binding site of the common β subunit of IL-3/granulocyte-macrophage colony-stimulating factor/IL-5 receptor. J.Immunol. 162 1496 PMID: 9973406

Adachi et al (1999) A novel lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation. J.Immunol. 163 939 PMID: 10395690

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关键词: Lyn peptide inhibitor, Lyn peptide inhibitor supplier, inhibitors, inhibits, Lyn, activation, IL-5, receptor, IL-3, Src, kinases, IL, receptors, Interleukin, cytokine, Cytokine, Receptors, Kinases, 2265, Tocris Bioscience

1 篇 Lyn peptide inhibitor 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Lyn peptide inhibitor 的部分引用包括：

Zhang et al (2018) Integrin CD11b negatively regulates Mincle-induced signaling via the Lyn-SIRPα-SHP1 complex. Exp Mol Med 50 e439 PMID: 29400702