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M62812

Cat. No. 5705 2 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5705 has been discontinued.

View all Toll-like Receptors products.
说明： TLR-4 inhibitor
化学名： 6-(2-Aminophenoxy)-1,2-benzisothiazol-3-amine dihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论 (1)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for M62812

M62812 is a TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic shock model.

化合物库 for M62812

M62812 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for M62812

分子量 330.23
公式 C13H11N3OS.2HCl
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 613263-00-6
PubChem ID 44224214
InChI Key SMTKPLISDFNJDJ-UHFFFAOYSA-N
Smiles NC1=CC=CC=C1OC2=CC=C3C(SN=C3N)=C2.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for M62812

参考文献是支持产品生物活性的出版物。

Nakamura et al (2007) Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur.J.Pharmacol. 569 237 PMID: 17588563

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关键词: M62812, M62812 supplier, Toll-like, receptors, inhibits, inhibitors, TLR-4, sepsis, septic, shock, Receptors, 5705, Tocris Bioscience

2 篇 M62812 的引用文献

引用文献是使用了 Tocris 产品的出版物。 M62812 的部分引用包括：

Nara et al (2020) TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model. Sci Rep 10 17451 PMID: 33060735

Jing et al (2020) Mucosal Vaccination for Influenza Protection Enhanced by Catalytic Immune-Adjuvant. Adv Sci (Weinh) 7 2000771 PMID: 32999833

M62812 的评论

平均评分: 3 (Based on 1 Review.)

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Ok, needs titrations.
By Scott Scarneo on 02/06/2019
分析类型： Ex Vivo
种属： Mouse
细胞系/组织： THP-1

We were interested in looking at LPS TLR4 mediated signaling and were hoping to use this to block this.

review image

Pathways for M62812

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.