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Macbecin I

Cat. No. 3061 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3061 has been discontinued.

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说明： Hsp90 inhibitor
化学名： (15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for Macbecin I

Macbecin I is an ansamycin antibiotic compound that inhibits Hsp90 activity (IC50 = 2 μM) by binding to the ATP-binding site. Exhibits antitumor and cytocidal activities (IC50 ~ 0.4 μM) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. Displays higher affinity and potency than geldanamycin (Cat. No. 1368).

技术数据 for Macbecin I

分子量 558.67
公式 C30H42N2O8
储存 Desiccate at -20°C
CAS Number 73341-72-7
PubChem ID 6436263
InChI Key PLTGBUPHJAKFMA-HXUNTIRESA-N
Smiles O=C1C=C([C@H](OC)[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](C)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Macbecin I

参考文献是支持产品生物活性的出版物。

Ono et al (1982) Antitumor and cytocidal activities of a newly isolated benzenoid ansamycin, macbecin I. Gann. 73 938 PMID: 6186564

Uehara et al (2003) Natural product origins of Hsp90 inhibitors. Curr.Cancer Drug Targets 3 325 PMID: 14529384

Martin et al (2008) Molecular characterization of macbecin as an Hsp90 inhibitor. J.Med.Chem. 51 2853 PMID: 18357975

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关键词: Macbecin I, Macbecin I supplier, Hsp90, inhibitors, inhibits, Heat, Shock, Protein, 90, MacbecinI, antibiotics, Antibiotics, 3061, Tocris Bioscience

1 篇 Macbecin I 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Macbecin I 的部分引用包括：

Alford and Brandman (2018) Quantification of Hsp90 availability reveals differential coupling to the heat shock response. J Cell Biol 217 3809 PMID: 30131327

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