Marimastat

Name: Marimastat
Brand: Tocris Bioscience
SKU: 2631
Rating: 5 (1 reviews)

Cat. No. 2631 22 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Broad spectrum MMP inhibitor

别名： BB 2516,Marimistat

化学名： (2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide

纯度： ≥99% (HPLC)

说明书

引用文献 (22)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Marimastat

Marimastat is a broad spectrum inhibitor of MMPs (IC₅₀ values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). Inhibits peritoneal dissemination of human gastric cancer cells in vivo through inhibition of tumor angiogenesis.

技术数据 for Marimastat

分子量	331.41
公式	C₁₅H₂₉N₃O₅
储存	Store at -20°C
纯度	≥99% (HPLC)
CAS Number	154039-60-8
PubChem ID	119031
InChI Key	OCSMOTCMPXTDND-OUAUKWLOSA-N
Smiles	O=C(NO)[C@@H](O)[C@H]([C@](N[C@@H]([C@](C)(C)C)C(NC)=O)=O)CC(C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Marimastat

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	33.14	100

制备储备液 for Marimastat

以下数据基于产品分子量 331.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.02 mL	15.09 mL	30.17 mL
5 mM	0.6 mL	3.02 mL	6.03 mL
10 mM	0.3 mL	1.51 mL	3.02 mL
50 mM	0.06 mL	0.3 mL	0.6 mL

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产品说明书 for Marimastat

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Marimastat

参考文献是支持产品生物活性的出版物。

Rasmussen and McCann (1997) Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat. Pharmacol.Ther. 75 69 PMID: 9364582

Wada et al (2003) Reduced angiogenesis in peritoneal dissemination of gastric cancer through gelatinase inhibition. Clin.Exp.Metastasis 20 431 PMID: 14524532

Bjornland et al (2005) Matrix metalloproteinases participate in osteosarcoma invasion. J.Surg.Res. 127 151 PMID: 16083752

If you know of a relevant reference for Marimastat, please let us know.

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