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MaxiPost

Cat. No. 4949 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potassium channel modulator; exerts subtype-specific effects
化学名： (3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MaxiPost

MaxiPost is a potassium channel modulator. Acts as a positive modulator at neuronal Kv7 channels and calcium-activated K+ channels (BKCa) in HEK293 cells. Displays negative modulatory activity at Kv7.1 channels (Ki = 3.7 μM) and GABAA receptors. Displays anxiolytic activity in vivo.

化合物库 for MaxiPost

MaxiPost is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for MaxiPost

分子量 359.7
公式 C16H10ClF4NO2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 187523-35-9
PubChem ID 214350
InChI Key ULYONBAOIMCNEH-HNNXBMFYSA-N
Smiles O=C2[C@]([C@]3=CC(Cl)=CC=C3OC)(F)C1=CC=C(C(F)(F)F)C=C1N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MaxiPost

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 35.97 100
ethanol 35.97 100

制备储备液 for MaxiPost

以下数据基于产品分子量 359.7。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.78 mL 13.9 mL 27.8 mL
5 mM 0.56 mL 2.78 mL 5.56 mL
10 mM 0.28 mL 1.39 mL 2.78 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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产品说明书 for MaxiPost

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for MaxiPost

参考文献是支持产品生物活性的出版物。

Korsgaard et al (2005) Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels. J.Pharmacol.Exp.Ther. 314 282 PMID: 15814569

Jepps et al (2012) One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders. Br.J.Pharmacol. 168 19 PMID: 22880633

Hamashima et al (2005) Catalytic enantioselective fluorination of oxindoles. J.Am.Chem.Soc. 127 10164 PMID: 16028916

If you know of a relevant reference for MaxiPost, please let us know.

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关键词: MaxiPost, MaxiPost supplier, potassium, channels, neuronal, Kv7, calcium, activated, K+, BK, GABAA, receptors, R-enantiomer, anxiolytic, anxiety, anxiolytics, Kv7.1, Voltage-Gated, Potassium, Channels, Ca2+-Activated, Receptors, 4949, Tocris Bioscience

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MaxiPost 的评论

平均评分: 5 (Based on 1 Review.)

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MaxiPost was used to study BK channel activation on HEK 293 cell line.
By Anonymous on 12/04/2018
分析类型： In Vitro
种属： Human
细胞系/组织： HEK 293

MaxiPost(BMS-204352) was used to study BK channel activation on HEK 293 cell line.

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