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MB 05032

Cat. No. 6618 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent FBPase inhibitor; promotes HSC expansion
化学名： P-[5-[2-Amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]phosphonic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MB 05032

MB 05032 is a potent FBPase inhibitor (EC50 values are 1.6, 29 and 61 nM for human liver FBPase, human muscle FBPase and rat liver FBPase). Promotes hematopoietic stem cell and progenitor cell expansion. Increases engraftment in primary NSG mice recipients. Also enhances myeloid and lymphoid chimerism in secondary NSG mouse recipients. Promotes glycolysis, glucose uptake and lactate production in umbilical cord blood CD34+ cells.

化合物库 for MB 05032

MB 05032 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for MB 05032

分子量 302.29
公式 C11H15N2O4PS
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 261365-11-1
PubChem ID 11289630
InChI Key XJMYIJPPDSZOPN-UHFFFAOYSA-N
Smiles CC(CC1=C(C2=CC=C(P(O)(O)=O)O2)N=C(S1)N)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MB 05032

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.23 100

制备储备液 for MB 05032

以下数据基于产品分子量 302.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.31 mL 16.54 mL 33.08 mL
5 mM 0.66 mL 3.31 mL 6.62 mL
10 mM 0.33 mL 1.65 mL 3.31 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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参考文献 for MB 05032

参考文献是支持产品生物活性的出版物。

Guo et al (2018) Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis. Nat.Med. 24 360 PMID: 29377004

van Poelje et al (2011) Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes. Handb.Exp.Pharmacol. 203 279 PMID: 21484576

If you know of a relevant reference for MB 05032, please let us know.

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关键词: MB 05032, MB 05032 supplier, MB05032, potent, FBPase, inhibitors, fructose, 1, 6, bisphosphatase, diabetes, HSC, expansion, gluconeogenesis, hematopoietic, haematopoietic, stem, cells, Other, Transferases, Stem, Cell, Proliferation, Hematopoietic, Cells, 6618, Tocris Bioscience

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