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Submit ReviewMCU i4
说明： Negative modulator of mitochondrial Ca2+ uniporter (MCU)
化学名： 4-[[4-(Diethylamino)phenyl]amino]-6-methyl-3-quinolinecarboxylic acid ethyl ester
纯度： ≥98% (HPLC)
生物活性 for MCU i4
MCU i4 is a negative modulator of mitochondrial calcium (Ca2+) uniporter (MCU) complex, which binds to MICU1, a regulatory protein within MCU complex. MCU i4 reduces mitochondrial Ca2+ uptake in multiple cell lines including MEFs, MDA-MB,231 and HEK293T cells, and demonstrates a negative effect on mitochondrial membrane potential. In ex vivo muscle fibres, MCU i4 reduces mitochondrial Ca2+ uptake and impairs muscle cell growth.
化合物库 for MCU i4
MCU i4 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for MCU i4
| 分子量 | 377.49 |
| 公式 | C23H27N3O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 371924-24-2 |
| PubChem ID | 1568449 |
| InChI Key | RIWXBJCWHVMATR-UHFFFAOYSA-N |
| Smiles | CCOC(=O)C1=C(NC2=CC=C(C=C2)N(CC)CC)C2=C(C=CC(C)=C2)N=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for MCU i4
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 18.87 | 50 | |
| ethanol | 37.75 | 100 |
制备储备液 for MCU i4
以下数据基于产品分子量 377.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.65 mL | 13.25 mL | 26.49 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.3 mL |
| 10 mM | 0.26 mL | 1.32 mL | 2.65 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
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产品说明书 for MCU i4
参考文献 for MCU i4
参考文献是支持产品生物活性的出版物。
Di Marco et al (2020) A high-throughput screening identifies MICU1 targeting compounds. Cell Rep. 30 2321 PMID: 32075766
If you know of a relevant reference for MCU i4, please let us know.
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关键词: MCU i4, MCU i4 supplier, MCUi4, MCU, mitochondrial, calcium, ca2+, uniporter, complex, negative, modulators, inhibitors, inhibits, modulates, MICU1, Mitochondrial, Calcium, Uniporter, 7195, Tocris Bioscience
1 篇 MCU i4 的引用文献
引用文献是使用了 Tocris 产品的出版物。 MCU i4 的部分引用包括：
Maria et al (2022) Mitochondria-Endoplasmic Reticulum Interplay Regulates Exo-Cytosis in Human Neuroblastoma Cells. Cells 11 PMID: 35159324
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