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Submit ReviewMDL 72222
说明： 5-HT3 antagonist
化学名： Tropanyl 3,5-dichlorobenzoate
纯度： ≥99% (HPLC)
生物活性 for MDL 72222
MDL 72222 is a 5-HT3 antagonist.
化合物库 for MDL 72222
MDL 72222 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for MDL 72222
| 分子量 | 314.21 |
| 公式 | C15H17Cl2NO2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 40796-97-2 |
| PubChem ID | 1683 |
| InChI Key | MNJNPLVXBISNSX-UHFFFAOYSA-N |
| Smiles | CN1C2CCC1CC(C2)OC(=O)C1=CC(Cl)=CC(Cl)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for MDL 72222
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 100 |
制备储备液 for MDL 72222
以下数据基于产品分子量 314.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.18 mL | 15.91 mL | 31.83 mL |
| 5 mM | 0.64 mL | 3.18 mL | 6.37 mL |
| 10 mM | 0.32 mL | 1.59 mL | 3.18 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
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产品说明书 for MDL 72222
参考文献 for MDL 72222
参考文献是支持产品生物活性的出版物。
Fozard (1984) MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors. Naunyn Schmiedebergs Arch.Pharmacol. 326 36 PMID: 6472484
Richardson and Engel (1986) The pharmacology and function of 5-HT3 receptors. Trends Neurosci. 9 424
If you know of a relevant reference for MDL 72222, please let us know.
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关键词: MDL 72222, MDL 72222 supplier, 5-HT3, antagonists, Serotonin, Receptors, MDL72222, 0640, Tocris Bioscience
6 篇 MDL 72222 的引用文献
引用文献是使用了 Tocris 产品的出版物。 MDL 72222 的部分引用包括：
Bocchio et al (2015) Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala. Neuropsychopharmacology 40 3015 PMID: 26052039
Jinka et al (2012) Inhibition of NMDA-type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (Urocitellus parryii). J Neurochem 122 934 PMID: 22697356
Dolma et al (2016) Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell 29 859 PMID: 27300435
Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572
Hampson et al (2007) Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia 50 1743 PMID: 17579833
Geerts et al (1999) Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. Br J Pharmacol 127 1327 PMID: 10455282
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MDL 72222 的评论
平均评分: 5 (Based on 1 Review.)
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Pharmacological block of 5-HT3 receptors.
By
Anonymous on 08/31/2019
分析类型： Ex Vivo
种属： Mouse
细胞系/组织： Cerebellum
MDL 72222 was used for pharmacological isolation of glycine receptors response in nucleated membrane patches pulled from cerebellar granule cells. Clear response was obtained, with characteristic conductance states pertinent to glycine receptor. Picture: recording of single-channel openings of glycine receptor with 10 microM MDL 72222 in perfusion solution.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.