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Medetomidine hydrochloride

Cat. No. 5160 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and highly selective α2 agonist
化学名： 4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Medetomidine hydrochloride

Medetomidine hydrochloride is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Inhibits twitch response in electrically stimulated mouse vas deferens (pD2 = 9.0). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

Active Isomer also available.

化合物库 for Medetomidine hydrochloride

Medetomidine hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Medetomidine hydrochloride

分子量 236.74
公式 C13H16N2.HCl
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 86347-15-1
PubChem ID 68601
InChI Key VPNGEIHDPSLNMU-UHFFFAOYSA-N
Smiles CC(C2=CN=CN2)C1=C(C)C(C)=CC=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Medetomidine hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 23.67 100
DMSO 23.67 100

制备储备液 for Medetomidine hydrochloride

以下数据基于产品分子量 236.74。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.22 mL 21.12 mL 42.24 mL
5 mM 0.84 mL 4.22 mL 8.45 mL
10 mM 0.42 mL 2.11 mL 4.22 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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产品说明书 for Medetomidine hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Medetomidine hydrochloride

参考文献是支持产品生物活性的出版物。

Savola et al (1986) Evidence for medetomidine as a selective and potent agonist at alpha 2-adrenoceptors. J.Aut.Pharmacol. 6 275 PMID: 2880852

Virtanen et al (1988) Characterization of the selectivity, specificity and potency of medetomidine as an α2-adrenoceptor agonist. Eur.J.Pharmacol. 150 9 PMID: 2900154

Scheinin et al (1989) Medetomidine - a novel α2-adrenoceptor agonist: a review of its pharmacodynamic effects. Prog.Neuro-Psychopharm.Biol.Psychiat. 13 635 PMID: 2571177

If you know of a relevant reference for Medetomidine hydrochloride, please let us know.

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关键词: Medetomidine hydrochloride, Medetomidine hydrochloride supplier, Potent, selective, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenoceptor, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, agonists, Receptors, Adrenergic, Alpha-2, 5160, Tocris Bioscience

2 篇 Medetomidine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Medetomidine hydrochloride 的部分引用包括：

Moura et al (2006) Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. Br J Pharmacol 149 1049 PMID: 17075569

Furuta et al (2009) Role of alpha2-adrenoceptors and glutamate mechanisms in the external urethral sphincter continence reflex in rats. J.Urol. 181 1467 PMID: 19157445

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