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Submit ReviewMelatonin
说明： Endogenous hormone; agonist at MT1 and MT2
化学名： N-Acetyl-5-methoxytryptamine
纯度： ≥99% (HPLC)
生物活性 for Melatonin
Melatonin is an endogenous hormone that acts as an agonist at melatonin receptors MT1 and MT2. Exhibits a prominent role in the control of circadian rhythm, displays immunomodulatory activity and acts as a powerful antioxidant in vivo.
化合物库 for Melatonin
Melatonin is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for Melatonin
| 分子量 | 232.28 |
| 公式 | C13H16N2O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 73-31-4 |
| PubChem ID | 896 |
| InChI Key | DRLFMBDRBRZALE-UHFFFAOYSA-N |
| Smiles | O=C(C)NCCC2=CNC1=CC=C(OC)C=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Melatonin
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 11.61 | 50 |
制备储备液 for Melatonin
以下数据基于产品分子量 232.28。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 8.61 mL | 43.05 mL | 86.1 mL |
| 2.5 mM | 1.72 mL | 8.61 mL | 17.22 mL |
| 5 mM | 0.86 mL | 4.31 mL | 8.61 mL |
| 25 mM | 0.17 mL | 0.86 mL | 1.72 mL |
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产品说明书 for Melatonin
参考文献 for Melatonin
参考文献是支持产品生物活性的出版物。
Bubenik (2008) Thirty four years since the discovery of gastrointestinal melatonin. J.Physiol.Pharmacol. 59 33 PMID: 18812627
Fischer et al (2008) Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair. Exp.Dermatol. 17 713 PMID: 18643846
Cardinali et al (2009) Melatonin and melatonergic drugs on sleep: possible mechanisms of action. Int.J.Neurosci. 119 821 PMID: 19326288
If you know of a relevant reference for Melatonin, please let us know.
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关键词: Melatonin, Melatonin supplier, Endogenous, hormone, agonists, MT1, MT2, Receptors, Melatonin, circadian, rhythms, (MT), 3550, Tocris Bioscience
10 篇 Melatonin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Melatonin 的部分引用包括：
Chen et al (2014) Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. Toxicol Sci 20 1298 PMID: 24574803
Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888
Hou et al (2017) Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats. Front Cell Neurosci 11 98 PMID: 28473754
Costa et al (2015) The brominated flame retardant BDE-47 causes oxidative stress and apoptotic cell death in vitro and in vivo in mice. Neurotoxicology 48 68 PMID: 25797475
Jie et al (2021) Melatonin Promotes Heterotopic Ossification Through Regulation of Endothelial-Mesenchymal Transition in Injured Achilles Tendons in Rats. Front Cell Dev Biol 9 629274 PMID: 33644068
Fernandes et al (2019) Melatonin and Leishmania amazonensis Infection Altered miR-294, miR-30e, and miR-302d Impacting on Tnf, Mcp-1, and Nos2 Expression. Front Cell Infect Microbiol 9 60 PMID: 30949455
Serge et al (2022) PDK4 Inhibition Ameliorates Melatonin Therapy by Modulating Cerebral Metabolism and Remyelination in an EAE Demyelinating Mouse Model of Multiple Sclerosis. Front Immunol 13 862316 PMID: 35355991
Huang et al (2010) Comparative cytotoxicity and intracellular accumulation of five polybrominated diphenyl ether congeners in mouse cerebellar granule neurons. Nature 114 124 PMID: 19969594
Vivek et al (2020) Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531. Elife 9 PMID: 32667883
Giordano et al (2008) Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels. Toxicol Appl Pharmacol 232 161 PMID: 18656495
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Melatonin 的评论
平均评分: 5 (Based on 1 Review.)
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Excellent choice for interaction studies with melatonin receptors.
By
Benjamin Stauch on 10/11/2022
分析类型： In Vitro
种属： Human
This product is an excellent choice for in vitro interaction studies with melatonin receptors. Given that its the endogenous ligand of these receptors, it offers an important point of comparison when testing ligands with unknown activity profiles. In our lab, we typically use this product in micromolar concentrations in all buffers when handling melatonin receptors, unless a more highly stabilizing or potent ligand (such as 2-phenylmelatonin or ramelteon) is needed. These ligands can be more expensive, making melatonin preferable in some cases. We found this product consistently of the highest quality. Highly recommended