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Submit ReviewMethylprednisolone
说明： Glucocorticoid receptor agonist
化学名： 11β,17β,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione
纯度： ≥99% (HPLC)
生物活性 for Methylprednisolone
Methylprednisolone is a glucocorticoid receptor (GR) agonist. Displays anti-inflammatory and antioxidant properties. Attenuates apoptosis in oligodendrocytes after injury stimuli. Upregulates expression of Bcl-xL via direct binding of the GR/STAT5 complex. Neuroprotective.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
化合物库 for Methylprednisolone
Methylprednisolone is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Methylprednisolone
| 分子量 | 374.47 |
| 公式 | C22H30O5 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 83-43-2 |
| PubChem ID | 6741 |
| InChI Key | VHRSUDSXCMQTMA-PJHHCJLFSA-N |
| Smiles | O=C1C=C[C@@]2(C)C([C@@H](C)C[C@]3([H])[C@@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3CC[C@](C(CO)=O)4O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Methylprednisolone
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 37.45 | 100 |
制备储备液 for Methylprednisolone
以下数据基于产品分子量 374.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.67 mL | 13.35 mL | 26.7 mL |
| 5 mM | 0.53 mL | 2.67 mL | 5.34 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.67 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
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产品说明书 for Methylprednisolone
参考文献 for Methylprednisolone
参考文献是支持产品生物活性的出版物。
Lee et al (2008) Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury. J.Neurosci. 29 3141 PMID: 18354017
Xu et al (2009) STAT5 mediates antiapoptotic effects of methylprednis. on oligodendrocytes. J.Neurosci. 29 2022 PMID: 19228956
If you know of a relevant reference for Methylprednisolone, please let us know.
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关键词: Methylprednisolone, Methylprednisolone supplier, Glucocorticoids, receptors, GR, agonists, anti-inflammatory, antioxidants, apoptosis, antiapoptosis, antiapoptotic, oligodendrocytes, Bcl-xL, Bcl-2, GR/STAT5, Neuroprotective, injury, Glucocorticoid, Receptor, Family, 4819, Tocris Bioscience
篇 Methylprednisolone 的引用文献
引用文献是使用了 Tocris 产品的出版物。
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Methylprednisolone 的评论
平均评分: 5 (Based on 1 Review.)
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Anti-inflammatory effects in neural tissue.
By
Luiz Alexandre Magno on 02/17/2022
分析类型： In Vivo
种属： Rat
This anti-inflammatory decreases inflammation in neural tissue. Pretreatment with this drug is able to decrease the proliferation of glial cells (see the image, right side). This experimental model is useful to create comparisons with new drugs to be tested.
Its is very important to perform a time response curve to get the best results.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.