Mexiletine hydrochloride

Cat. No. 2596 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Na⁺ channel blocker; antiarrhythmic agent

别名： Ko 1173

化学名： 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride

纯度： ≥99% (HPLC)

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Mexiletine hydrochloride

Mexiletine hydrochloride is an use-dependent sodium channel blocker (IC₅₀ values are 75.3 and 23.6 μM for tonic and use-dependent block respectively). Class Ib antiarrhythmic, neuroprotective and antimyotonic agent.

化合物库 for Mexiletine hydrochloride

Mexiletine hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Mexiletine hydrochloride

分子量	215.72
公式	C₁₁H₁₇NO.HCl
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	5370-01-4
PubChem ID	21467
InChI Key	NFEIBWMZVIVJLQ-UHFFFAOYSA-N
Smiles	Cl.CC(N)COC1=C(C)C=CC=C1C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Mexiletine hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	21.57	100
	DMSO	21.57	100

制备储备液 for Mexiletine hydrochloride

以下数据基于产品分子量 215.72。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	4.64 mL	23.18 mL	46.36 mL
5 mM	0.93 mL	4.64 mL	9.27 mL
10 mM	0.46 mL	2.32 mL	4.64 mL
50 mM	0.09 mL	0.46 mL	0.93 mL

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产品说明书 for Mexiletine hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Mexiletine hydrochloride

参考文献是支持产品生物活性的出版物。

Franchini et al (2003) Optically active mexil. analogues as stereoselective blockers of voltage-gated Na⁺ channels. J.Med.Chem. 46 5238 PMID: 14613326

Ates et al (2006) Neuroprotective effect of mexil. in the central nervous system of diabetic rats. Mol.Cell.Biochem. 286 125 PMID: 16541198

Bellis et al (2006) Evaluation of the pharmacological activity of the major mexil. metabolites on skeletal muscle sodium currents. Br.J.Pharmacol. 149 300 PMID: 16921388

If you know of a relevant reference for Mexiletine hydrochloride, please let us know.

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关键词: Mexiletine hydrochloride, Mexiletine hydrochloride supplier, Na+, channel, blockers, antiarrhythmic, agent, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Ko1173, Ko, 1173, Voltage-gated, 2596, Tocris Bioscience

2 篇 Mexiletine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Mexiletine hydrochloride 的部分引用包括：

Rojas et al (2014) Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress. Front Cell Neurosci 8 24 PMID: 24570655

Rojas et al (2015) Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling. Front Cell Neurosci 9 203 PMID: 26106294

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