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Submit ReviewMG 624
Discontinued Product
1356 has been discontinued.
说明： α7 neuronal nAChR antagonist
化学名： N,N,N-Triethyl-2-[4-(2-phenylethenyl)phenoxy]ethanaminium iodide
纯度： ≥98% (HPLC)
生物活性 for MG 624
MG 624 is a selective antagonist for neuronal α7 subunit- containing nAChR subtypes. Inhibits α-Bgtx binding to chick α7 and α4β2 subtypes with Ki values of 106 nM and 84 μM respectively.
技术数据 for MG 624
| 分子量 | 451.39 |
| 公式 | C22H30NOI |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 77257-42-2 |
| PubChem ID | 6433339 |
| InChI Key | RDTKUZXIHMTSJO-UEIGIMKUSA-M |
| Smiles | [I-].CC[N+](CC)(CC)CCOC1=CC=C(\C=C\C2=CC=CC=C2)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MG 624
参考文献 for MG 624
参考文献是支持产品生物活性的出版物。
Gotti et al (1998) 4-Oxystilbene compounds are selective ligands for neuronal nicotinic abungarotoxin receptors. Br.J.Pharmacol. 124 1197 PMID: 9720791
Maggi et al (1999) Selective effects of a 4-oxystilbene derivative on wild and mutant neuronal chick α7 nicotinic receptor. Br.J.Pharmacol. 126 285 PMID: 10051147
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关键词: MG 624, MG 624 supplier, α7, alpha7, neuronal, nicotinic, receptor, antagonist, a7, Receptors, Acetylcholine, nAChR, MG624, Nicotinic, (a7), 1356, Tocris Bioscience
3 篇 MG 624 的引用文献
引用文献是使用了 Tocris 产品的出版物。 MG 624 的部分引用包括：
Chang et al (2015) Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin. Sci Rep 5 10256 PMID: 26194093
Dolma et al (2016) Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell 29 859 PMID: 27300435
Cassilly et al (2016) SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. Int J Clin Exp Pathol 11 e0154932 PMID: 27183222
MG 624 的评论
平均评分: 5 (Based on 1 Review.)
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The 5,760 bioactive compound library is a collated compound set of approved drugs and biologically active compound.
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Anonymous on 02/01/2020
分析类型： In Vitro
种属： Other
Biologically active compounds that have been documented to interact with awide range of targets including SB-224289 (Cat. # 1221), MG-624 (Cat.# 1356), GVIA (Cat. No. 1085), DPAT hydrobromide (Cat. No. 1080) and valinomycin (VA; Cat. # 3373) were ordered from Tocris Bioscience
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.