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Submit Review(-)-MK 801 maleate
说明： NMDA antagonist; less active enantiomer of (+)-MK 801
化学名： (5R,10S)-(-)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cylcohepten-5,10-imine maleate
纯度： ≥99% (HPLC)
生物活性 for (-)-MK 801 maleate
(-)-MK 801 maleate is a less active enantiomer (10-fold less potent in behavioral studies) than (+)-MK 801 maleate.
(+)-enantiomer also available.
化合物库 for (-)-MK 801 maleate
(-)-MK 801 maleate is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for (-)-MK 801 maleate
| 分子量 | 337.37 |
| 公式 | C16H15N.C4H4O4 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 121917-57-5 |
| PubChem ID | 16219612 |
| InChI Key | QLTXKCWMEZIHBJ-FWHYOZOBSA-N |
| Smiles | O=C(O)/C=C\C(O)=O.C[C@@]14C3=C(C=CC=C3)C[C@H](N4)C2=C1C=CC=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for (-)-MK 801 maleate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 8.43 | 25 温和加热 | |
| DMSO | 33.74 | 100 |
制备储备液 for (-)-MK 801 maleate
以下数据基于产品分子量 337.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.96 mL | 14.82 mL | 29.64 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.93 mL |
| 10 mM | 0.3 mL | 1.48 mL | 2.96 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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产品说明书 for (-)-MK 801 maleate
参考文献 for (-)-MK 801 maleate
参考文献是支持产品生物活性的出版物。
Genovese and Lu (1991) Effects of MK-801 stereoisomers on schedule-controlled behavior in rats. Psychopharmacology. 105 477 PMID: 1771215
Thompson et al (1990) Synthesis and pharmacological evaluation of a series of dibenzo[a,d]cycloalkenimines as N-MthD.-aspartate antagonists. J.Med.Chem. 33 789 PMID: 1688947
If you know of a relevant reference for (-)-MK 801 maleate, please let us know.
按产品操作查看相关产品
关键词: (-)-MK 801 maleate, (-)-MK 801 maleate supplier, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, (-)-MK801, maleate, MK801, 0955, Tocris Bioscience
3 篇 (-)-MK 801 maleate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (-)-MK 801 maleate 的部分引用包括：
Huang et al (2007) Actin polymerization and ERK phosphorylation are required for Arc/Arg3.1 mRNA targeting to activated synaptic sites on dendrites. J Neurosci 27 9054 PMID: 17715342
Yang et al (2005) Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake. J Pharmacol Exp Ther 25 4288 PMID: 15858055
Huang et al (2004) Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J Neurosci 24 4551 PMID: 15140926
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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