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Submit Review(-)-Quinpirole hydrochloride
说明： Selective D2-like agonist
化学名： (4aR-trans)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline hydrochloride
纯度： ≥98% (HPLC)
生物活性 for (-)-Quinpirole hydrochloride
(-)-Quinpirole hydrochloride is a selective dopamine D2 receptor agonist (Ki values are 4.8, ~24, ~30 and 1900 nM at D2, D3, D4 and D1 receptors respectively).
许可信息
Sold with the permission of Eli Lilly and Company
化合物库 for (-)-Quinpirole hydrochloride
(-)-Quinpirole hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for (-)-Quinpirole hydrochloride
| 分子量 | 255.79 |
| 公式 | C13H21N3.HCl |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 85798-08-9 |
| PubChem ID | 55397 |
| InChI Key | HJHVRVJTYPKTHX-HTMVYDOJSA-N |
| Smiles | Cl.[H][C@]12CCCN(CCC)[C@]1([H])CC1=CNN=C1C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for (-)-Quinpirole hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 25.58 | 100 | |
| DMSO | 6.39 | 25 |
制备储备液 for (-)-Quinpirole hydrochloride
以下数据基于产品分子量 255.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.91 mL | 19.55 mL | 39.09 mL |
| 5 mM | 0.78 mL | 3.91 mL | 7.82 mL |
| 10 mM | 0.39 mL | 1.95 mL | 3.91 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.78 mL |
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产品说明书 for (-)-Quinpirole hydrochloride
参考文献 for (-)-Quinpirole hydrochloride
参考文献是支持产品生物活性的出版物。
Levant et al (1996) Modulation of [3H]quinpirole binding in brain by monoamine oxidase inhibitors: evidence for a potential novel binding site. J.Pharmacol.Exp.Ther. 278 145 PMID: 8764345
Seeman and Van Tol (1994) DA receptor pharmacology. Trends Pharmacol.Sci. 15 264 PMID: 7940991
Sullivan et al (1998) Effects of quinpirole on central DA systems in sensitized and non-sensitized rats. Neuroscience 83 781 PMID: 9483561
If you know of a relevant reference for (-)-Quinpirole hydrochloride, please let us know.
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关键词: (-)-Quinpirole hydrochloride, (-)-Quinpirole hydrochloride supplier, Selective, D2-like, agonists, Dopamine, Non-Selective, Receptors, dopaminergic, Non-selective, 1061, Tocris Bioscience
39 篇 (-)-Quinpirole hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (-)-Quinpirole hydrochloride 的部分引用包括：
Tozzi et al (2015) Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system. Front Cell Neurosci 9 192 PMID: 26074768
Gantz et al (2011) Loss of Mecp2 in substantia nigra DA neurons compromises the nigrostriatal pathway. J Neurosci 31 12629 PMID: 21880923
Dorst et al (2020) Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nat Commun 11 5113 PMID: 33037215
Snyder et al (2017) Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness. J Biol Chem 292 7208 PMID: 28275053
Leng et al (2017) Activation of DRD5 inhibits tumor growth by autophagic cell death. Autophagy 13 1404 PMID: 28613975
Pedersen et al (2021) A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors. J Biol Chem 296 100503 PMID: 33684444
Choi (2017) Role of DA D2 receptor in stress-induced myelin loss. Sci Rep 7 11654 PMID: 28912499
Ahmadiantehrani and Ron (2013) DA D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268. J Neurochem PMID: 23373701
Chuhma et al (2009) DA neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection. Neuroscience 164 1068 PMID: 19729052
Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888
Leyrer-Jackson (2017) Subtype-specific effects of DArgic D2 receptor activation on synaptic trains in layer V pyramidal neurons in the mouse prefrontal cortex. Physiol Rep 5 e13499 PMID: 29150590
Xing et al (2015) DA D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells. Neuropsychopharmacology 9 310 PMID: 26388722
Wang et al (2015) A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in DA D2 and D3 receptor agonist-induced autophagy activation. Proc Natl Acad Sci U S A 11 2057 PMID: 26649942
Shin et al (2015) Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens. Nat Neurosci 112 8124 PMID: 26080439
Luque-Rojas et al (2013) Hyperactivity induced by the DA D2/D3 receptor agonist quinpirole is attenuated by inhibitors of endocannabinoid degradation in mice. Int J Neuropsychopharmacol 16 661 PMID: 22647577
Napolitano et al (2010) Role of aberrant striatal DA D1 receptor/cAMP/protein kinase A/DARPP32 signaling in the paradoxical calming effect of amphetamine. J Neurosci 30 11043 PMID: 20720111
Verharen et al (2019) Differential contributions of striatal dopamine D1 and D2 receptors to component processes of value-based decision making. Neurophsychopharmacology 44 2195 PMID: 31254972
Lassus et al (2018) Glutamatergic and dopaminergic modulation of cortico-striatal circuits probed by dynamic calcium imaging of networks reconstructed in microfluidic chips. Sci Rep 8 17461 PMID: 30498197
Burgess et al (2010) DArgic regulation of sleep and cataplexy in a murine model of narcolepsy. Sleep 33 1295 PMID: 21061851
Higley and Sabatini (2010) Competitive regulation of synaptic Ca2+ influx by D2 DA and A2A adenosine receptors. Nat Neurosci 13 958 PMID: 20601948
Zhang (2018) DA Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs. Invest Ophthalmol Vis Sci 59 4441 PMID: 30193315
Matsui and Alvarez (2018) Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep 23 3852 PMID: 29949769
Jain et al (2018) Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. Am J Physiol Endocrinol Metab 315 E357 PMID: 29812984
Beas et al (2018) The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism. Nat Neurosci 21 963 PMID: 29915192
Borgs et al (2016) DArgic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects. Scientific Reports 6 33377 PMID: 27640816
Picton et al (2016) Mechanisms underlying the endogenous DArgic inhibition of spinal locomotor circuit function in Xenopus tadpoles. Scientific Reports 6 35749 PMID: 27760989
Spulber et al (2014) PFOS induces behavioral alterations, including spontaneous hyperactivity that is corrected by dexamfetamine in zebrafish larvae. PLoS One 9 e94227 PMID: 24740186
Deng et al (2010) MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. J Biol Chem 13 1128 PMID: 20711186
Goffin et al (2010) DA-dependent tuning of striatal inhibitory synaptogenesis. Neuron 30 2935 PMID: 20181591
Dai et al (2018) Selective blockade of spinal D2DR by levo-corydalmine attenuates MOR tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner. Exp Mol Med 50 148 PMID: 30429454
Ferraro et al (2012) A novel mechanism of cocaine to enhance DA d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study. J Neurosci 37 1856 PMID: 22453136
Hutchinson et al (2012) Differential regulation of MeCP2 phosphorylation in the CNS by DA and serotonin. Eur J Neurosci 37 321 PMID: 21956448
Hook et al (2012) DArgic modulation of ganglion-cell photoreceptors in rat. Autophagy 35 507 PMID: 22304466
Yoon et al (2011) Wnt5a-DA D2 receptor interactions regulate DA neuron development via extracellular signal-regulated kinase (ERK) activation. Neuropsychopharmacology 286 15641 PMID: 21454669
González-Maeso et al (2007) Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. PLoS One 53 439 PMID: 17270739
Zapata et al (2007) Regulation of DA transporter function and cell surface expression by D3 DA receptors. J Biol Chem 282 35842 PMID: 17923483
Kitada et al (2007) Impaired DA release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc Natl Acad Sci U S A 104 11441 PMID: 17563363
Melis et al (2004) Endocannabinoids mediate presynaptic inhibition of glutamatergic transmission in rat ventral tegmental area DA neurons through activation of CB1 receptors. J Neurosci 24 53 PMID: 14715937
Marchese et al (2003) Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications. Br J Pharmacol 140 520 PMID: 12970091
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Inhibition of Synaptic Transmission in the VP.
By
Anonymous on 02/02/2020
分析类型： In Vivo
种属： Mouse
quinpirole(1 μΜ)
Quinpirole reduces evoked dopamine release.
By
Anonymous on 03/28/2018
分析类型： Ex Vivo
种属： Mouse
Voltammetry experiments were used to measure evoked dopamine release. Quinpirole (30nM) reduces dopamine release considerably (near IC50 in dorsal striatum), which was reversed by sulpiride (600nM). Drug works every time!
Goes into water well. We usually make up a 1 mM stock for many experiments.
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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