(-)-U-50488 hydrochloride

Name: (-)-U-50488 hydrochloride
Brand: Tocris Bioscience
SKU: 0496
Rating: 5 (2 reviews)

Cat. No. 0496 1 次引用 2 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective κ agonist; more active enantiomer of (±)-U-50488 (Cat. No. 0495)

化学名： trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (1)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for (-)-U-50488 hydrochloride

(-)-U-50488 hydrochloride is a more active enantiomer of (±)-U-50488.

Racemate and (+)-enantiomer also available.

技术数据 for (-)-U-50488 hydrochloride

分子量	405.79
公式	C₁₉H₂₆Cl₂N₂O.HCl
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	114528-79-9
PubChem ID	9931141
InChI Key	KGMMGVIYOHGOKQ-APTPAJQOSA-N
Smiles	O=C(CC3=CC(Cl)=C(Cl)C=C3)N([C@@H]1[C@@H](N2CCCC2)CCCC1)C.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (-)-U-50488 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water		100
	DMSO	40.58	100

制备储备液 for (-)-U-50488 hydrochloride

以下数据基于产品分子量 405.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.32 mL	24.64 mL
5 mM	0.49 mL	2.46 mL	4.93 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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产品说明书 for (-)-U-50488 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (-)-U-50488 hydrochloride

参考文献是支持产品生物活性的出版物。

De Costa et al (1987) Synthesis and absolute configuration of optically pure enantiomers of a κ-opioid receptor selective antagonist. FEBS Lett. 223 335 PMID: 2822490

Morrone et al (1993) Withdrawal contractures of guinea-pig isolated ileum after acute activation of κ opioid receptors. Br.J.Pharmacol. 109 48 PMID: 8388301

Reddy and Bhargava (1993) Effect of chronic administration of U-50,488H, a kappa opioid receptor agonist on central DA (D₂) receptors of the rat. Eur.J.Pharmacol. 235 23 PMID: 8390939

Zhu et al (1998) Agonist-induced desensitization and down-regulation of the human kappa opioid receptor expressed in chinese hamster ovary cells. J.Pharmacol.Exp.Ther. 285 28 PMID: 9535991

If you know of a relevant reference for (-)-U-50488 hydrochloride, please let us know.

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关键词: (-)-U-50488 hydrochloride, (-)-U-50488 hydrochloride supplier, selective, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, Kappa, Opioid, 0496, Tocris Bioscience

1 篇 (-)-U-50488 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (-)-U-50488 hydrochloride 的部分引用包括：

Pirino et al (2020) Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis Neuropharmacology 181 108341 PMID: 33011200

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(-)-U-50488 hydrochloride 的评论

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Presto-Tango.

By Anonymous on 06/15/2021

分析类型： In Vitro

种属： Human

Dose response curve of beta arrestin recruitment

Works very well.

By Luca Zangrandi on 03/05/2020

分析类型： In Vitro

种属： Human

细胞系/组织： CHO

Agonist-induced ERK phosphorylation in CHO cells.

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