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Submit ReviewMirtazapine
说明： Potent 5-HT2 antagonist; also 5-HT3, H1 and α2 antagonist; antidepressant
别名： Org 3770,6-Azamianserin
化学名： 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
纯度： ≥99% (HPLC)
生物活性 for Mirtazapine
Mirtazapine is an antidepressant agent; potent 5-HT2, 5-HT3 and histamine H1 receptor antagonist and moderately potent α2-adrenoceptor antagonist (pKi values are 8.05, ~ 8.1, 9.3 and 6.95 respectively). Enhances noradrenaline (NA) release in rat brain via inhibition of α2-adrenergic autoreceptors and displays only weak affinity for monoamine transporters (pKi values are 5.6, < 5 and < 5.1 for inhibition of NA, dopamine and 5-HT uptake respectively). Increases hippocampal NA and 5-HT levels in rats following systemic administration in vivo.
化合物库 for Mirtazapine
Mirtazapine is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Mirtazapine
| 分子量 | 265.36 |
| 公式 | C17H19N3 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 85650-52-8 |
| PubChem ID | 4205 |
| InChI Key | RONZAEMNMFQXRA-UHFFFAOYSA-N |
| Smiles | CN1CCN2C(C1)C1=CC=CC=C1CC1=C2N=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Mirtazapine
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| ethanol | 13.27 | 50 | |
| DMSO | 5.31 | 20 |
制备储备液 for Mirtazapine
以下数据基于产品分子量 265.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 7.54 mL | 37.68 mL | 75.37 mL |
| 2.5 mM | 1.51 mL | 7.54 mL | 15.07 mL |
| 5 mM | 0.75 mL | 3.77 mL | 7.54 mL |
| 25 mM | 0.15 mL | 0.75 mL | 1.51 mL |
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产品说明书 for Mirtazapine
参考文献 for Mirtazapine
参考文献是支持产品生物活性的出版物。
de Boer et al (1988) Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, ORG 3770 and its enantiomers. Neuropharmacology 27 399 PMID: 3419539
Kooyman et al (1994) Interaction between enantiomers of mianserin and ORG3770 at 5-HT3 receptors in cultured mouse neuroblastoma cells. Neuropharmacology 33 501 PMID: 7984289
de Boer et al (1996) Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazepine, mianserin and idazoxan. J.Pharmacol.Exp.Ther. 277 852 PMID: 8627567
If you know of a relevant reference for Mirtazapine, please let us know.
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关键词: Mirtazapine, Mirtazapine supplier, Potent, 5-HT3, antagonists, 5-HT2, H1, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenoceptor, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, Antidepressant, Serotonin, Receptors, Non-Selective, Histamine, histaminergic, Org3770, depression, Org, 3770, 6-Azamianserin, Non-selective, Adrenergic, Alpha-2, 2018, Tocris Bioscience
2 篇 Mirtazapine 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Mirtazapine 的部分引用包括：
Midkiff et al (2011) Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS One 6 e25395 PMID: 21966518
Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Cancer Res 7 2336 PMID: 26114334
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.