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Submit ReviewMithramycin A
说明： Inhibitor of DNA and RNA polymerase
化学名： (1S)-5-Deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dideoxy-β-D-arabino-hexopyranosyl)-β-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-β-D-ribo-hexopyranosyl-(1.fwdarw.3)-O-2,6-dideoxy-β-D-lyxo-hexopyranosyl-(1.fwdarw.3)-2,6-dideoxy-β-D-arabino-hexopyranosyl)oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-1-O-methyl-D-threo-2-pentulose
纯度： ≥95% (HPLC)
生物活性 for Mithramycin A
Mithramycin A is an anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.
技术数据 for Mithramycin A
| 分子量 | 1085.16 |
| 公式 | C52H76O24 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 18378-89-7 |
| PubChem ID | 90479798 |
| InChI Key | CFCUWKMKBJTWLW-YZCDWGPJSA-N |
| Smiles | OC1=C2C(C=C3C(C([C@@H](OC5OC(C)C(O)C(OC6OC(C)C(O)C(OC7OC(C)C(O)C(O)(C)C7)C6)C5)[C@@]([C@H](OC)C([C@@H](O)[C@H](O)C)=O)([H])C3)=O)=C2O)=CC(O[C@@H]4OC(C)C(O)C(OC8OC(C)C(O)C(O)C8)C4)=C1C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Mithramycin A
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 54.26 | 50 |
制备储备液 for Mithramycin A
以下数据基于产品分子量 1085.16。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 1.84 mL | 9.22 mL | 18.43 mL |
| 2.5 mM | 0.37 mL | 1.84 mL | 3.69 mL |
| 5 mM | 0.18 mL | 0.92 mL | 1.84 mL |
| 25 mM | 0.04 mL | 0.18 mL | 0.37 mL |
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产品说明书 for Mithramycin A
参考文献 for Mithramycin A
参考文献是支持产品生物活性的出版物。
Demicheli and Garnier-Suillerot (1991) Mithramycin cannot bind to left-handed poly(dG-m5dC) in the presence of Mg2+ ion. Biochem.Biophys.Res.Commun. 177 511 PMID: 1828342
Miller et al (1987) Mithramycin selectively inhibits transcription of G-C containing DNA. Am.J.Med.Sci. 294 388 PMID: 2962490
Ray et al (1990) Mithramycin selectively inhibits the transcriptional activity of a transfected human c-myc gene. Am.J.Med.Sci. 300 203 PMID: 2147360
If you know of a relevant reference for Mithramycin A, please let us know.
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关键词: Mithramycin A, Mithramycin A supplier, inhibitors, inhibits, DNA, RNA, polymerases, MithramycinA, antibiotics, DNA,, and, Protein, Synthesis, Polymerase, Antibiotics, 1489, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Plicamycin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
6 篇 Mithramycin A 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Mithramycin A 的部分引用包括：
Oh et al (2015) Arachidonic acid promotes skin wound healing through induction of human MSC migration by MT3-MMP-mediated fibronectin degradation. J Neurosci 6 e1750 PMID: 25950480
Huang et al (2012) Prostaglandin E2 increases fibroblast gene-specific and global DNA methylation via increased DNA methyltransferase expression. FASEB J 26 3703 PMID: 22645246
Corsini et al (2007) Role of SP-1 in SDS-induced adipose differentiation related protein synthesis in human keratinocytes. Gene Regul Syst Bio 1 207 PMID: 19936089
Siddesha et al (2014) Acetylsalicylic acid inhibits IL-18-induced cardiac fibroblast migration through the induction of RECK. J Cell Physiol 229 845 PMID: 24265116
Huang et al (2016) Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress. Cell Res 26 1112 PMID: 27644987
Duverger et al (2004) The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF). Cell Death Dis 90 2025 PMID: 15138489
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Mithramycin A 的评论
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Mithramycin A completely kills melanoma cell line at micromolar concentrations.
By
Anonymous on 02/07/2019
分析类型： In Vitro
种属： Human
细胞系/组织： SK-MEL-28
Used for killing assay for in vitro cell culture. Cells were cultured for 24 hours before the addition of the compound into the media at low micromolar concentrations (indicated by the arrow).
