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Discontinued Product
5799 has been discontinued.
View all Insulin and Insulin-like Receptors products.
说明： Insulin sensitizer; exhibits low binding affinity at PPARγ
别名： CAY 10415,MSDC 0160
化学名： 5-[[4-[2-(5-Ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione
纯度： ≥98% (HPLC)
生物活性 for Mitoglitazone
Mitoglitazone is an insulin sensitizer; enhances insulin sensitivity and lowers blood-glucose levels in diabetic mouse models. Inhibits mitochondria pyruvate carriers; increases mitochondrial respiration rates, leading to a reduction in expression of lipogenic enzymes. Suppresses gluconeogenesis and lipogenesis in primary hepatocytes. Exhibits low binding affinity and activity at PPARγ (EC50 = 23.7 μM).
技术数据 for Mitoglitazone
| 分子量 | 370.42 |
| 公式 | C19H18N2O4S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 146062-49-9 |
| PubChem ID | 10429242 |
| InChI Key | IRNJSRAGRIZIHD-UHFFFAOYSA-N |
| Smiles | CCC1=CC=C(C(COC2=CC=C(C=C2)CC3SC(NC3=O)=O)=O)N=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Mitoglitazone
参考文献 for Mitoglitazone
参考文献是支持产品生物活性的出版物。
Divakaruni et al (2013) Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc.Natl.Acad.Sci.U.S.A. 110 5422 PMID: 23513224
Chen et al (2012) Ins resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione. J.Biol.Chem. 287 23537 PMID: 22621923
Colca et al (2013) Identification of a mitochondrial target of thiazolidinedione Ins sensitizers (mTOT) relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One 8 e61551 PMID: 23690925
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关键词: Mitoglitazone, Mitoglitazone supplier, Antidiabetic, neurodegeneration, Alzheimer's, Parkinson's, diseases, mTOT, target, thiazolidinones, insulin, resistance, mitochondria, metabolism, pyruvate, carriers, MPC, hyperglycemia, CAY, 10415, MSDC, 0160, Insulin, and, insulin-like, Receptors, Insulin-like, PPARgamma, 5799, Tocris Bioscience
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Pathways for Mitoglitazone
