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Submit ReviewML 10302 hydrochloride
说明： Potent and selective 5-HT4 partial agonist
化学名： 4-Amino-5-chloro-2-methoxybenzoic acid 2-(1-piperidinyl)ethyl ester hydrochloride
纯度： ≥99% (HPLC)
生物活性 for ML 10302 hydrochloride
ML 10302 hydrochloride is a potent 5-HT4 partial agonist (EC50 = 4 nM) that displays > 680-fold selectivity over 5-HT3 receptors (Ki values are 1.07 and 730 nM respectively). Increases sAPPα levels in the cortex in an animal model of Alzheimer's disease and exhibits progastrokinetic effects in vivo.
技术数据 for ML 10302 hydrochloride
| 分子量 | 349.25 |
| 公式 | C15H21ClN2O3.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 186826-17-5 |
| PubChem ID | 56972230 |
| InChI Key | HBLRTSYSGOFQCK-UHFFFAOYSA-N |
| Smiles | ClC1=CC(C(OCCN2CCCCC2)=O)=C(OC)C=C1N.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ML 10302 hydrochloride
参考文献 for ML 10302 hydrochloride
参考文献是支持产品生物活性的出版物。
Yang et al (1997) New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J.Med.Chem. 40 608 PMID: 9046352
Cachard-Chastel et al (2007) 5-HT4 receptor agonists increase sAPPα levels in the cortex and hippocampus of male C57BL/6j mice. Br.J.Pharmacol. 150 883 PMID: 17325649
Ponti et al (2001) Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon. Neurogastroenterol.Mot. 13 543
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关键词: ML 10302 hydrochloride, ML 10302 hydrochloride supplier, Potent, selective, 5-HT4, partial, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, ML10302, hydrochloride, 3499, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.