ML 133 hydrochloride

Name: ML 133 hydrochloride
Brand: Tocris Bioscience
SKU: 4549
Rating: 5 (1 reviews)

Cat. No. 4549 4 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： K_ir2 channel blocker

化学名： N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ML 133 hydrochloride

ML 133 hydrochloride is a selective blocker of inwardly rectifying K_ir2 potassium channels (IC₅₀ values are 1.8, 2.8, 2.9 and 4.0 μM at pH 7.4 for mK_ir2.1, hK_ir2.6, hK_ir2.2 and hK_ir2.3 respectively). Exhibits no effect on rK_ir1.1 (IC₅₀ > 300 μM); displays weak activity at hK_ir7.1 and rK_ir4.1 (IC₅₀ values are 33 and 76 μM).

技术数据 for ML 133 hydrochloride

分子量	313.82
公式	C₁₉H₁₉NO.HCl
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	1222781-70-5
PubChem ID	44247466
InChI Key	NGQIBUUFXDPHKT-UHFFFAOYSA-N
Smiles	COC(C=C3)=CC=C3CNCC1=C(C=CC=C2)C2=CC=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 133 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	31.38	100

制备储备液 for ML 133 hydrochloride

以下数据基于产品分子量 313.82。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.19 mL	15.93 mL	31.87 mL
5 mM	0.64 mL	3.19 mL	6.37 mL
10 mM	0.32 mL	1.59 mL	3.19 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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产品说明书 for ML 133 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ML 133 hydrochloride

参考文献是支持产品生物活性的出版物。

Wang et al (2011) Selective inhibition of the K_ir2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. ACS Chem.Biol. 6 845 PMID: 21615117

Wu et al (2010) A potent and selective small molecule K_ir2.1 inhibitor. Probe Reports from the NIH Molecular Libraries Pro PMID: 21433384

If you know of a relevant reference for ML 133 hydrochloride, please let us know.

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关键词: ML 133 hydrochloride, ML 133 hydrochloride supplier, ML133, hydrochloride, Kir2, Kir2.x, Kir2.1, Kir2.6, Kir2.2, Kir2.3, inhibitors, inhibits, inward, rectifier, potassium, channels, IRK1, KCNJ2, IRK2, hIRK, IRK3, hIRK2, Inward, Potassium, Channels, 4549, Tocris Bioscience

4 篇 ML 133 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ML 133 hydrochloride 的部分引用包括：

Lively et al (2018) Comparing Effects of Transforming Growth Factor β1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels. Front Cell Neurosci 12 115 PMID: 29780305

Lam and Schlichter (2015) Expression and contributions of the Kir2.1 inward-rectifier K(+) channel to proliferation, migration and chemotaxis of microglia in unstimulated and anti-inflammatory states. Nat Commun 9 185 PMID: 26029054

Sung-Joong et al (2021) Roles of Cytokines in the Temporal Changes of Microglial Membrane Currents and Neuronal Excitability and Synaptic Efficacy in ATP-Induced Cortical Injury Model. Int J Mol Sci 22 PMID: 34202215

Siddiqui et al (2016) Complex molecular and functional outcomes of single versus sequential cytokine stimulation of rat microglia. J Neuroinflammation 13 66 PMID: 27009332

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