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ML 184

Cat. No. 6668 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective GPR55 agonist; also promotes NSC proliferation and differentiation
别名： CID 20440433
化学名： 3-[[4-(2,3-Dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML 184

ML 184 is a selective GPR55 agonist (EC50 = 250 nM). Exhibits >100-fold selectivity for GPR55 over GPR35, CB1 and CB2. Increases proliferation of neural stem cells and promotes neuronal differentiation in vitro.

化合物库 for ML 184

ML 184 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for ML 184

分子量 470.63
公式 C25H34N4O3S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 794572-10-4
PubChem ID 2440433
InChI Key VRSJAHQGJHDACS-UHFFFAOYSA-N
Smiles CN(S(=O)(C1=CC(C(N2CCN(C3=C(C(C)=CC=C3)C)CC2)=O)=C(N4CCCC4)C=C1)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 184

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 9.41 20

制备储备液 for ML 184

以下数据基于产品分子量 470.63。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 10.62 mL 53.12 mL 106.24 mL
1 mM 2.12 mL 10.62 mL 21.25 mL
2 mM 1.06 mL 5.31 mL 10.62 mL
10 mM 0.21 mL 1.06 mL 2.12 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for ML 184

参考文献是支持产品生物活性的出版物。

Hill et al (2018) Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. Br.J.Pharmacol. 175 3407 PMID: 29888782

Kotsikorou et al (2011) Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry 50 5633 PMID: 21534610

If you know of a relevant reference for ML 184, please let us know.

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关键词: ML 184, ML 184 supplier, ML184, gpr55, agonists, agonism, selective, neural, stem, cell, proliferation, differentiation, NSC, CID, 20440433, GPR55, Neural, Stem, Cells, 6668, Tocris Bioscience

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