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Submit ReviewML 18
说明： BRS-3 antagonist; also GRPR agonist
化学名： (αS)-N-[[1-(4-Methoxyphenyl)cyclohexyl]methyl-α-[[[(4-nitrophenyl)amino]carbonyl]amino]-1H-indole-3-propanamide
纯度： ≥98% (HPLC)
生物活性 for ML 18
Bombesin receptor subtype 3 (BRS-3) antagonist (IC50 = 4.8 μM). Also binds GRPR (IC50 = 16 μM). Inhibits BA1-stimulated cytosolic Ca2+ and suppresses cell proliferation in a lung cancer model in vitro.
技术数据 for ML 18
| 分子量 | 569.65 |
| 公式 | C32H35N5O5 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1422269-30-4 |
| PubChem ID | 91827363 |
| InChI Key | JOKVJNCYOSFDGC-LJAQVGFWSA-N |
| Smiles | O=C(NCC1(C2=CC=C(OC)C=C2)CCCCC1)[C@@H](NC(NC3=CC=C([N+]([O-])=O)C=C3)=O)CC4=CNC5=CC=CC=C54 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ML 18
参考文献 for ML 18
参考文献是支持产品生物活性的出版物。
Moody et al (2015) ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. Peptides 64 55 PMID: 25554218
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关键词: ML 18, ML 18 supplier, ML18, Bombesin, receptors, BRS, 3, PD168368, neuromedin, B, NMBR, gastrin, releasing, peptide, GRPR, lung, cancer, Receptors, 5599, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.