Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewML 213
说明： KV7.2 and KV7.4 channel opener
化学名： N-(2,4,6-Trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide
纯度： ≥99% (HPLC)
生物活性 for ML 213
ML 213 is a selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50 values are 230 and 510 nM for KV7.2 and KV7.4 respectively). Displays > 80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay. Hyperpolarizes resting membrane potential in an in vitro spinal cord preparation.
化合物库 for ML 213
ML 213 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for ML 213
| 分子量 | 257.37 |
| 公式 | C17H23NO |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 489402-47-3 |
| PubChem ID | 3111211 |
| InChI Key | SIQGKPGBLYKQBB-UHFFFAOYSA-N |
| Smiles | O=C(NC3=C(C)C=C(C)C=C3C)C1CC2CCC1C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for ML 213
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 12.87 | 50 | |
| ethanol | 12.87 | 50 |
制备储备液 for ML 213
以下数据基于产品分子量 257.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 7.77 mL | 38.85 mL | 77.71 mL |
| 2.5 mM | 1.55 mL | 7.77 mL | 15.54 mL |
| 5 mM | 0.78 mL | 3.89 mL | 7.77 mL |
| 25 mM | 0.16 mL | 0.78 mL | 1.55 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for ML 213
参考文献 for ML 213
参考文献是支持产品生物活性的出版物。
Yu et al (2011) Discovery, synthesis, and structure activity relationship of a series of N-aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a novel KCNQ2 and KCNQ4 potassium channel opener. ACS Chem.Neurosci. 2 572 PMID: 22125664
Vicente-Baz et al (2016) Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine. Neuropharmacology 109 131 PMID: 27263036
If you know of a relevant reference for ML 213, please let us know.
关键词: ML 213, ML 213 supplier, ML213, KCNQ2, KCNQ4, channels, openers, kv7.2, kv7.4, potassium, K+, voltage, gated, Kv, Voltage-Gated, Potassium, Channels, 4519, Tocris Bioscience
2 篇 ML 213 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ML 213 的部分引用包括：
Vincente-Baz et al (2016) Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine. Neuropharmacology 109 131 PMID: 27263036
Brueggemann et al (2014) Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol.Pharmacol. 86 330 PMID: 24944189
您是否知道使用了 Tocris ML 213 的优秀论文？ 请告知我们.
ML 213 的评论
平均评分: 5 (Based on 1 Review.)
Have you used ML 213?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
ML 213 was used to study Kv11.1 channel activation.
By
Sadequl Islam on 11/07/2018
分析类型： In Vitro
种属： Human
ML 213 was recently used to understand its effect on Kv11.1 and overall voltage gating mechanism. Different level of activation was observed.
