ML 218 hydrochloride

Cat. No. 4507 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Ca_V3.x blocker

化学名： 3,5-Dichloro-N-[[(1α,5α,6-exo,6α)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hex-6-yl]methyl]-benzamide hydrochloride

纯度： ≥99% (HPLC)

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ML 218 hydrochloride

ML 218 hydrochloride is a selective inhibitor of T-type calcium channels (IC₅₀ values are 270 and 310 nM for Ca_v3.3 and Ca_v3.2 respectively in a patch EP assay). Decreases burst activity in STN neurons; reduces cataleptic behaviour in an in vivo rat model of Parkinson's disease. Displays no significant inhibition of L- or N-type calcium channels, K_ir6 (K_ATP) or K_V11.1 (hERG) potassium channels. ML 218 hydrochloride inhibits oral cancer cell proliferation. Orally active.

化合物库 for ML 218 hydrochloride

ML 218 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ML 218 hydrochloride

分子量	405.79
公式	C₁₉H₂₆Cl₂N₂O.HCl
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	2319922-08-0
PubChem ID	2723792
InChI Key	JIQFFACVQXXHMY-YDALLXLXSA-N
Smiles	CC(C)(C)CCN1C[C@@]2([H])[C@@]([C@@H]2CNC(C3=CC(Cl)=CC(Cl)=C3)=O)([H])C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 218 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	36.93	100
	ethanol	36.93	100

制备储备液 for ML 218 hydrochloride

以下数据基于产品分子量 405.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.32 mL	24.64 mL
5 mM	0.49 mL	2.46 mL	4.93 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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产品说明书 for ML 218 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ML 218 hydrochloride

参考文献是支持产品生物活性的出版物。

Xiang et al (2011) The discovery and characterization of ML218: A novel, centrally active T-type calcium channel inhibitor with robust effects in STN neurons and in a rodent model of Parkinson's disease. ACS Chem.Neurosci. 2 730 PMID: 22368764

Galvan et al (2016) Lack of antiparkinsonian effects of systemic injections of the specific T-type calcium channel blocker ML218 in MPTP-treated monkeys. ACS Chem.Neurosci 7 1543 PMID: 27596273

Chakraborty et al (2021) ML218 HCl is more efficient than capsaicin in inhibiting bacterial antigen-induced Cal 27 oral cancer cell proliferation. Int.J.Mol.Sci. 22 12559 PMID: 34830441

If you know of a relevant reference for ML 218 hydrochloride, please let us know.

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关键词: ML 218 hydrochloride, ML 218 hydrochloride supplier, ML218, HCl, CID45115620, T-type, calcium, channels, CAV3.1, CAV3.2, CAV3.3, inhibitors, inhibits, selective, Cav3.x, Channels, 4507, Tocris Bioscience