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ML 252

Cat. No. 4687 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective KV7.2 inhibitor; brain penetrant
化学名： (S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML 252

ML 252 is a potent and selective inhibitor of KV7.2 voltage-gated potassium channels (IC50 = 70 nM), which displays >40-fold selectivity for KV7.2 over KV7.1 channels (IC50 = 2.9 μM for KV7.1). ML 252 is the (S)-enantiomer, and is more potent than the (R)-enantiomer or racemic mixture (IC50 values are 944 and 160 nM, respectively). ML 252 displays selectivity for KV7.2 over a panel of >68 GPCRs, ion channels and transporters; inhibits melatonin MT1 receptor 60% at 10 μM. ML 252 is brain penetrant.

化合物库 for ML 252

ML 252 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ML 252

分子量 308.43
公式 C20H24N2O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1392494-64-2
PubChem ID 26873419
InChI Key FROGGFONBYACJB-UHFFFAOYSA-N
Smiles O=C([C@@H](CC)C1=CC=CC=C1)NC2=C(N3CCCC3)C=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 252

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.84 100
ethanol 30.84 100

制备储备液 for ML 252

以下数据基于产品分子量 308.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.21 mL 32.42 mL
5 mM 0.65 mL 3.24 mL 6.48 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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参考文献 for ML 252

参考文献是支持产品生物活性的出版物。

Cheung et al (2012) Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of KV7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phe J.Med.Chem. 55 6975 PMID: 22793372

If you know of a relevant reference for ML 252, please let us know.

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关键词: ML 252, ML 252 supplier, ML252, voltage, gated, potassium, channel, Kv7.2, inhibitor, inhibits, potent, brain, penetrant, selective, Voltage-Gated, Potassium, Channels, 4687, Tocris Bioscience

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