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ML 277

Cat. No. 4777 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective KV7.1 (KCNQ1) potassium channel activator; augments IKs current
化学名： (2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML 277

ML 277 is a selective Kv7.1 (KCNQ1) potassium channel activator (EC50 = 260 nM). Exhibits >100-fold selectivity versus KCNQ2, KCNQ4 and hERG potassium channels. Augments IKs current of cultured human cardiomyocytes and shortens action potential duration.

化合物库 for ML 277

ML 277 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ML 277

分子量 471.59
公式 C23H25N3O4S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1401242-74-7
PubChem ID 53347902
InChI Key OXQNLLVUVDAEHC-OAQYLSRUSA-N
Smiles O=[C@@]([C@H]3CCCCN3S(C4=CC=C(C)C=C4)(=O)=O)NC1=NC(C2=CC=C(OC)C=C2)=CS1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 277

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 47.16 100

制备储备液 for ML 277

以下数据基于产品分子量 471.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.12 mL 10.6 mL 21.2 mL
5 mM 0.42 mL 2.12 mL 4.24 mL
10 mM 0.21 mL 1.06 mL 2.12 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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参考文献 for ML 277

参考文献是支持产品生物活性的出版物。

Mattmann et al (2012) Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective Kv7.1 (KCNQ1) potassium channel activator. Bioorg.Med.Chem.Lett. 22 5936 PMID: 22910039

Yu et al (2013) Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels. Proc.Natl.Acad.Sci.U.S.A. 110 8732 PMID: 23650380

If you know of a relevant reference for ML 277, please let us know.

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关键词: ML 277, ML 277 supplier, ML277, kv7.1, channel, activators, activates, KCNQ1, selective, IKs, currents, long, QT, syndrome, LQTS, Voltage-Gated, Potassium, Channels, 4777, Tocris Bioscience

篇 ML 277 的引用文献

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ML 277 的评论

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ML 277 is a good voltage gated K+ channel activator.
By Anonymous on 10/23/2018
分析类型： In Vitro
种属： Human

ML 277 is being used on our lab for its selective channel activation properties. It shows great Kv channel opening properties. Have been used in published papers and the data produced are consistent.

Dissolve in DMSO. For sterile conditions, use sterile DMSO.

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