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Submit ReviewML 347
说明： Potent and selective ALK1 and ALK2 inhibitor
别名： LDN 193719,1lWY,VU0469381
化学名： 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
纯度： ≥98% (HPLC)
生物活性 for ML 347
ML 347 is a potent and selective ALK2 and ALK1 inhibitor (IC50 values are 32 and 46 nM, respectively); displays >200 fold selectivity over ALK3 and ALK6 and >400 fold selectivity over VEGF2. Exhibits no activity at ALK4, ALK5 or in a panel of related kinases. Inhibits BMP4 signaling in a functional assay (IC50 = 152 nM).
化合物库 for ML 347
ML 347 is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。
技术数据 for ML 347
| 分子量 | 352.39 |
| 公式 | C22H16N4O |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1062368-49-3 |
| PubChem ID | 44577753 |
| InChI Key | FVRYPYDPKSZGNS-UHFFFAOYSA-N |
| Smiles | COC(C=C3)=CC=C3C(C=N2)=CN1C2=C(C4=CC=CC5=C4C=CC=N5)C=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for ML 347
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 7.05 | 20 |
制备储备液 for ML 347
以下数据基于产品分子量 352.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 14.19 mL | 70.94 mL | 141.89 mL |
| 1 mM | 2.84 mL | 14.19 mL | 28.38 mL |
| 2 mM | 1.42 mL | 7.09 mL | 14.19 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.84 mL |
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产品说明书 for ML 347
参考文献 for ML 347
参考文献是支持产品生物活性的出版物。
Engers et al (2013) Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN Bioorg Med Chem Lett. 23 3248 PMID: 23639540
If you know of a relevant reference for ML 347, please let us know.
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关键词: ML 347, ML 347 supplier, ML347, Potent, selective, ALK1, ALK2, BMP, activin, receptor, like, kinase, Bone, morphogenetic, proteins, inhibitors, inhibits, LDN, 193719, 1LWY, VU0469381, and, Other, Activin, Receptors, 4945, Tocris Bioscience
2 篇 ML 347 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ML 347 的部分引用包括：
Varadaraj et al (2015) Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia. Neoplasia 17 826 PMID: 26678910
Kathleen et al (2022) Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer. Cell Rep 40 111066 PMID: 35905726
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Pathways for ML 347
