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ML 382

Cat. No. 5738 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： MRGPRX1 positive allosteric modulator
化学名： 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML 382

ML 382 is a selective MRGPRX1 positive allosteric modulator (EC50 = 190 nM). Exhibits selectivity for MrgX1 over MrgX2, MrgC11 and a panel of 68 other GPCRs, ion channels and transporters. Enhances BAM (8-22) potency at MRGPRX1 by 7-fold.

技术数据 for ML 382

分子量 360.43
公式 C18H20N2O4S
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 1646499-97-9
PubChem ID 71598556
InChI Key RCSLEKLNDJJJLF-UHFFFAOYSA-N
Smiles O=C(NC1=C(OCC)C=CC=C1)C2=C(NS(C3CC3)(=O)=O)C=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 382

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.04 100
ethanol 7.21 20 温和加热

制备储备液 for ML 382

以下数据基于产品分子量 360.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.87 mL 27.74 mL
5 mM 0.55 mL 2.77 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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参考文献 for ML 382

参考文献是支持产品生物活性的出版物。

Wen et al (2015) Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1. ChemMedChem 10 57 PMID: 25209672

If you know of a relevant reference for ML 382, please let us know.

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关键词: ML 382, ML 382 supplier, ML382, VU0485891, MrgX1,, SNSR4, sensory, neuron-specific, receptors, positive, allosteric, modulators, selective, PAM, Mas-related, G, Protein-Coupled, Receptors, 5738, Tocris Bioscience

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