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ML 67-33

Cat. No. 6886 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) channel activator
化学名： 2,7-Dichloro-9,10-dihydro-9,9-dimethyl-10-[2-(2H-tetrazol-5-yl)ethyl]acridine
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML 67-33

ML 67-33 is a K2P potassium channel activator (EC50 values are 21.8 - 29.4 μM, 30.2 μM and 27.3 μM for K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) respectively, expressed in xenopus oocytes). Increases channel currents by activating core gating apparatus of channels. In a mouse migraine model, ML 67-33 improves pain symptoms via activation of TREK 1/2 currents in trigeminal ganglion sensory neurons.

化合物库 for ML 67-33

ML 67-33 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ML 67-33

分子量 374.27
公式 C18H17Cl2N5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1443290-89-8
PubChem ID 86272454
InChI Key GQPMJOXQJUGJPG-UHFFFAOYSA-N
Smiles CC1(C2=CC(Cl)=CC=C2N(C3=CC=C(C=C13)Cl)CCC4=NN=NN4)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 67-33

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 37.43 100

制备储备液 for ML 67-33

以下数据基于产品分子量 374.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.36 mL 26.72 mL
5 mM 0.53 mL 2.67 mL 5.34 mL
10 mM 0.27 mL 1.34 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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产品说明书 for ML 67-33

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for ML 67-33

参考文献是支持产品生物活性的出版物。

Bagriantsev et al (2013) A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels. ACS Chem.Biol. 8 1841 PMID: 23738709

Pope et al (2018) Protein and chemical determinants of BL-1249 action and selectivity for K2P channels. ACS Chem.Neurosci. 9 3153 PMID: 30089357

Prado et al (2021) TREK channel activation suppresses migraine pain phenotype. iScience 24 102961 PMID: 34458705

If you know of a relevant reference for ML 67-33, please let us know.

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关键词: ML 67-33, ML 67-33 supplier, ML67-33, K2P, potassium, channel, K2P2.1, K2P10.1, K2P4.1, TREK1, TREK2, TRAAK, activators, activates, Two-P, Potassium, Channels, 6886, Tocris Bioscience

1 篇 ML 67-33 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ML 67-33 的部分引用包括：

Prado et al (2021) TREK channel activation suppresses migraine pain phenotype. iScience 24 102961 PMID: 34458705

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