主页 / 药理学 / Enzymes / Proteases / ACE2 / ACE2 Inhibitors / MLN 4760

MLN 4760

Cat. No. 3345 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective angiotensin-converting enzyme 2 (ACE2) inhibitor
化学名： N-[(1S)-1-Carboxy-3-methylbutyl]-3-[(3,5-dichlorophenyl)methyl]-L-histidine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MLN 4760

MLN 4760 is a highly potent, cell-permeable and selective inhibitor of angiotensin converting enzyme 2 (ACE2) (IC50 = 0.44 nM). MLN 4760 inhibits production of angiotensin (1-7) from angiotensin II and reduces ACE2 expression and activity in an animal model of lung inflammation.

技术数据 for MLN 4760

分子量 428.31
公式 C19H23Cl2N3O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 305335-31-3
PubChem ID 448281
InChI Key NTCCRGGIJNDEAB-UHFFFAOYSA-N
Smiles ClC1=CC(CN2C(C[C@H](N[C@@H](CC(C)C)C(O)=O)C(O)=O)=CN=C2)=CC(Cl)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MLN 4760

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 42.83 100

制备储备液 for MLN 4760

以下数据基于产品分子量 428.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.67 mL 23.35 mL
5 mM 0.47 mL 2.33 mL 4.67 mL
10 mM 0.23 mL 1.17 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for MLN 4760

参考文献是支持产品生物活性的出版物。

Mores et al (2008) Development of potent and selective phosphinic peptide inhibitors of angiotensin-converting enzyme 2. J.Med.Chem. 51 2216 PMID: 18324760

Sodhi et al (2019) A dynamic variation of pulmonary ACE2 is required to modulate neutrophilic inflammation in response to Pseudomonas aeruginosa lung infection in mice. J.Immunol. 203 3000 PMID: 31645418

If you know of a relevant reference for MLN 4760, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 ACE2 Inhibitors

关键词: MLN 4760, MLN 4760 supplier, MLN4760, C-16, C16, angiotensin, converting, enzyme, ACE2, selective, potent, inhibitors, inhibition, carboxypeptidase, 3345, Tocris Bioscience

篇 MLN 4760 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 MLN 4760 的引用文献。 您是否知道使用了 Tocris MLN 4760 的优秀论文？ 请告知我们.

MLN 4760 的评论

目前没有该产品的评论。 Be the first to review MLN 4760 and earn rewards!

Have you used MLN 4760?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review