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说明： Potent dolastatin 10 analog; antitumor
化学名： N-Methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
纯度： ≥98% (HPLC)
生物活性 for MMAE
Potent, synthetic, cytotoxic analog of dolastatin 10 (Cat. No. 3375). Suppresses tumor cell viability in vitro (GIC50 values are 0.22, 0.49 and 0.54 nM in BT474, MDA-MB-361-DYT2 and N87 cells, respectively). MMAE derivatives have been shown to induce regression of established tumor xenografts when conjugated to tumor targeting antibodies via a protease-cleavable linker.
技术数据 for MMAE
| 分子量 | 717.98 |
| 公式 | C39H67N5O7 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 474645-27-7 |
| PubChem ID | 11542188 |
| InChI Key | DASWEROEPLKSEI-UIJRFTGLSA-N |
| Smiles | O=C(C[C@@H](OC)[C@@H](N(C)[C@@]([C@H](C(C)C)NC([C@H](C(C)C)NC)=O)=O)[C@@H](C)CC)N1[C@@]([C@@H]([C@H](C(N[C@@H]([C@@H](O)[C@]2=CC=CC=C2)C)=O)C)OC)([H])CCC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MMAE
参考文献 for MMAE
参考文献是支持产品生物活性的出版物。
Doronina et al (2003) Development of potent monoclonal antibody auristatin conjugates for cancer therapy. Nat.Biotechnol. 21 778 PMID: 12778055
Maderna et al (2014) Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications. J.Med.Chem. 57 10527 PMID: 25431858
关键词: MMAE, MMAE supplier, monomethylauristatin, E, Potent, cytotoxic, dolastatin, 10, analogues, anticancer, antitumour, antitumor, tubulin, polymerization, agents, Microtubules, Mitosis, 5683, Tocris Bioscience
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
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- DNA Damage Repair
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- Ubiquitin Proteasome Pathway
- Chemotherapy Targets