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说明： Potent TMEM16A (Anoctamin-1) blocker
化学名： 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid
纯度： ≥98% (HPLC)
生物活性 for MONNA
MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 = 80 nM). Exhibits >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR. Induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions. Carbachol (Cat. No. 2810) induced contraction of bronchial myocytes is reduced by MONNA and intracellular calcium release is increased.
技术数据 for MONNA
| 分子量 | 338.31 |
| 公式 | C18H14N2O5 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1572936-83-4 |
| PubChem ID | 72165188 |
| InChI Key | JIVRLHBAUUZTNC-UHFFFAOYSA-N |
| Smiles | COC1=CC(NC2=C(C(O)=O)C=C([N+]([O-])=O)C=C2)=CC3=C1C=CC=C3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for MONNA
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 33.83 | 100 |
制备储备液 for MONNA
以下数据基于产品分子量 338.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.96 mL | 14.78 mL | 29.56 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.91 mL |
| 10 mM | 0.3 mL | 1.48 mL | 2.96 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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产品说明书 for MONNA
参考文献 for MONNA
参考文献是支持产品生物活性的出版物。
Oh et al (2013) MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1. Mol.Pharmacol. 84 726 PMID: 23997117
Boedtkjer et al (2015) New selective inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh) -A01 and MONNA - what do they inhibit? Br.J.Pharmacol. 172 4158 PMID: 26013995
Dwivedi et al (2023) The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells. Eur.J.Pharmacol. PMID: 36967079
If you know of a relevant reference for MONNA, please let us know.
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关键词: MONNA, MONNA supplier, CaCC, TMEM16A, blockers, blocks, calcium-activated, chloride, channels, anoctamin-1, ANO1, potent, Ca2+-Activated, Chloride, Channels, 5770, Tocris Bioscience
2 篇 MONNA 的引用文献
引用文献是使用了 Tocris 产品的出版物。 MONNA 的部分引用包括：
Armen et al (2022) Evidence for tetrodotoxin-resistant spontaneous myogenic contractions of mouse isolated stomach that are dependent on acetylcholine. Br J Pharmacol 179 1187-1200 PMID: 34519057
Dwivedi et al (2023) The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells Eur J Pharmacol PMID: 36967079
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for MONNA
