Montelukast sodium

Cat. No. 5904 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： CysLT₁ and GPR17 antagonist

化学名： 1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt

纯度： ≥99% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Montelukast sodium

Montelukast sodium is a cysteinyl leukotriene receptor 1 (CysLT₁) and GPR17 antagonist. Blocks pentylenetetrazole-induced seizures, blood brain barrier (BBB) disruption and leukocyte migration in mice. Reduces neuroinflammation, improves BBB integrity, enhances learning and memory, and restores hippocampal neurogenesis and cognitive function in aged rats. Orally active and brain penetrant.

化合物库 for Montelukast sodium

Montelukast sodium is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Montelukast sodium

分子量	608.17
公式	C₃₅H₃₅ClNNaO₃S
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	151767-02-1
PubChem ID	23663996
InChI Key	LBFBRXGCXUHRJY-HKHDRNBDSA-M
Smiles	CC(O)(C1=C(C=CC=C1)CC[C@H](C2=CC(/C=C/C3=NC4=CC(Cl)=CC=C4C=C3)=CC=C2)SCC5(CC5)CC(O[Na])=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Montelukast sodium

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	30.41	50
	DMSO	60.82	100

制备储备液 for Montelukast sodium

以下数据基于产品分子量 608.17。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.64 mL	8.22 mL	16.44 mL
5 mM	0.33 mL	1.64 mL	3.29 mL
10 mM	0.16 mL	0.82 mL	1.64 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

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产品说明书 for Montelukast sodium

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Montelukast sodium

参考文献是支持产品生物活性的出版物。

Lenz et al (2014) Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood-brain barrier dysfunction. Neuroscience 277 859 PMID: 25090924

Marschallinger et al (2015) Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug. Nat.Commun. 6 8466 PMID: 26506265

If you know of a relevant reference for Montelukast sodium, please let us know.

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Leukotriene and Related Receptors

关键词: Montelukast sodium, Montelukast sodium supplier, Leukotriene, D4, antagonists, antagonism, cysteinyl, receptors, CysLT1, seizures, blood, brain, barrier, disruption, epilepsy, GPR17, and, Related, Receptors, 5904, Tocris Bioscience

1 篇 Montelukast sodium 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Montelukast sodium 的部分引用包括：

Wright et al (2019) Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2. Biochem Biophys Res Commun 520 35 PMID: 31564414

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