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Mpro 13b-K

Cat. No. 7228 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Coronavirus Mpro inhibitor
化学名： tert-Butyl (1-((S)-1-(((S)-4-(benzylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-3-cyclopropyl-1-oxopropan-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)carbamate
纯度： ≥97% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Mpro 13b-K

Mpro 13b-K is a coronavirus Mpro inhibitor (IC50 values are 0.12, 0.58 and 0.9 μM for recombinant Mpro from SARS-CoV-2, MERS-CoV and SARS-CoV, respectively). Mpro 13b-K inhibits SARS-CoV-2 infection of human Calu3 cells (IC50 = 2.4 μM). The compound also inhibits SARS-CoV-2 replication in A549-ACE2-TMPRSS2, VeroE6 and Huh7 cell cultures (EC50 values are 0.84, 1.3 and 3.4 μM). Exhibits oral and inhalative bioavailability.

Please note that this product was previously known as Mpro 13b.

许可信息

Sold under license from the University of Lübeck

技术数据 for Mpro 13b-K

分子量 593.68
公式 C31H39N5O7
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 2412965-59-2
PubChem ID 146026181
InChI Key NLVRHQFXQFSBQK-XWGVYQGASA-N
Smiles CC(C)(OC(NC1=CC=CN(C1=O)[C@H](C(N[C@H](C(C(NCC2=CC=CC=C2)=O)=O)C[C@@H]3CCNC3=O)=O)CC4CC4)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Mpro 13b-K

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 59.37 100

制备储备液 for Mpro 13b-K

以下数据基于产品分子量 593.68。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.68 mL 8.42 mL 16.84 mL
5 mM 0.34 mL 1.68 mL 3.37 mL
10 mM 0.17 mL 0.84 mL 1.68 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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产品说明书 for Mpro 13b-K

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Mpro 13b-K

参考文献是支持产品生物活性的出版物。

Zhang et al (2020) Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors. Science 368 409 PMID: 32198291

Cooper et al (2022) Diastereomeric resolution yields highly potent inhibitor of SARS-CoV-2 main protease. J.Med.Chem. 65 13328 PMID: 36179320

If you know of a relevant reference for Mpro 13b-K, please let us know.

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