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Mpro 61

Cat. No. 7695 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent non-covalent inhibitor of SARS-CoV-2 main protease
化学名： 5-[5-[3-Chloro-5-[(2-chlorophenyl)methoxy]-4-fluorophenyl]-6-oxo[1(6H),3'-bipyridin]-3-yl]-1-methyl-2,4(1H,3H)-pyrimidinedione
纯度： ≥95% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Mpro 61

Mpro 61 is a potent non-covalent inhibitor of SARS-CoV-2 main protease (IC50 = 44 nM, EC50 = 0.175 μM in the replicon assay and EC50 = 0.08 μM in the infectious SARS-CoV-2 assay); it is cell permable and exhibits no apparent cytotoxicity.

许可信息

Sold under license from Yale University. U.S. patent application number 63/135,062.

技术数据 for Mpro 61

分子量 565.38
公式 C28H19Cl2FN4O4
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2679814-93-6
PubChem ID 156587560
InChI Key KIJKUSPNZALBLD-UHFFFAOYSA-N
Smiles CN1C=C(C2=CN(C3=CN=CC=C3)C(C(C4=CC(OCC5=C(C=CC=C5)Cl)=C(C(Cl)=C4)F)=C2)=O)C(NC1=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Mpro 61

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 11.31 20

制备储备液 for Mpro 61

以下数据基于产品分子量 565.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 8.84 mL 44.22 mL 88.44 mL
1 mM 1.77 mL 8.84 mL 17.69 mL
2 mM 0.88 mL 4.42 mL 8.84 mL
10 mM 0.18 mL 0.88 mL 1.77 mL

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产品说明书 for Mpro 61

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Mpro 61

参考文献是支持产品生物活性的出版物。

Zhang et al (2021) Optimization of triarylpyridinone inhibitors of the main protease of SARS-CoV-2 to low-nanomolar antiviral potency. ACS Med.Chem.Lett. 12 1325 PMID: 34408808

If you know of a relevant reference for Mpro 61, please let us know.

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关键词: Mpro 61, Mpro 61 supplier, MPro61, potent, Triarylpyridinones, Inhibitors, inhibits, SARS-CoV-2, Main, Proteases, Antivirals, water, soluble, Coronavirus, 3C, and, 3CL, 7695, Tocris Bioscience

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