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Submit ReviewMS 21570
说明： GPR171 antagonist
化学名： N-Methyl-5-[(phenylmethyl)thio]-1,3,4-thiazadiazol-2-amine
纯度： ≥98% (HPLC)
生物活性 for MS 21570
MS 21570 is a GPR171 antagonist (IC50 = 220 nM). Inhibits BigLEN (Cat.No. 6304) mediated increases in [35S]GTPγS binding in hypothalamic membranes and hyperpolarization of basolateral amygdala pyramidal neurons. Reduces anxiety-like behavior and fear conditioning in mice.
化合物库 for MS 21570
MS 21570 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for MS 21570
| 分子量 | 237.34 |
| 公式 | C10H11N3S2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 65373-29-7 |
| PubChem ID | 805117 |
| InChI Key | KFLNRVSOQJTXDG-UHFFFAOYSA-N |
| Smiles | CNC1=NN=C(S1)SCC2=CC=CC=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for MS 21570
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 23.73 | 100 | |
| ethanol | 23.73 | 100 |
制备储备液 for MS 21570
以下数据基于产品分子量 237.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.21 mL | 21.07 mL | 42.13 mL |
| 5 mM | 0.84 mL | 4.21 mL | 8.43 mL |
| 10 mM | 0.42 mL | 2.11 mL | 4.21 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.84 mL |
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产品说明书 for MS 21570
参考文献 for MS 21570
参考文献是支持产品生物活性的出版物。
Bobeck et al (2017) The BigLEN-GPR171 peptide receptor system within the basolateral amygdala regulates anxiety-like behavior and contextual fear conditioning. Neuropsychopharmacology 42 2527 PMID: 28425495
If you know of a relevant reference for MS 21570, please let us know.
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关键词: MS 21570, MS 21570 supplier, MS21570, GPR171, antagonists, antagonism, bigLEN, anxiety, 6298, Tocris Bioscience
1 篇 MS 21570 的引用文献
引用文献是使用了 Tocris 产品的出版物。 MS 21570 的部分引用包括：
Richard D et al (2021) The GPR171 pathway suppresses T cell activation and limits antitumor immunity. Nat Commun 12 5857 PMID: 34615877
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