N⁶-Cyclohexyladenosine

Name: N 6 -Cyclohexyladenosine
Brand: Tocris Bioscience
SKU: 6863

Cat. No. 6863 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6863 has been discontinued.

View all Adenosine A<sub>1</sub> Receptors products.

说明： High affinity A₁ receptor agonist

化学名： N-Cyclohexyladenosine

纯度： ≥98% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for N⁶-Cyclohexyladenosine

N⁶-Cyclohexyladenosine is a high affinity adenosine A₁ receptor agonist (K_d values are 0.7 and 6 nM for bovine and guinea pig brain membranes, respectively). Reduces light-induced circadian phase delays. Exhibits protective effect in lysolecithin-induced demyelination model. When administered prior to ischemia, improves functional recovery of heart in a mouse model of ischemia-reperfusion injury. Induces hypothermia following icv administration in mice.

化合物库 for N⁶-Cyclohexyladenosine

N6-Cyclohexyladenosine is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for N⁶-Cyclohexyladenosine

分子量	349.38
公式	C₁₆H₂₃N₅O₄
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	36396-99-3
PubChem ID	9841284
InChI Key	SZBULDQSDUXAPJ-XNIJJKJLSA-N
Smiles	OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(NC3CCCCC3)N=CN=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for N⁶-Cyclohexyladenosine

分析证书/产品说明书

化学品安全技术说明书

参考文献 for N⁶-Cyclohexyladenosine

参考文献是支持产品生物活性的出版物。

Bruns et al (1980) Adenosine receptors in brain membranes: binding of N6-cyclohexyl[³H]adenosine and 1,3-diethyl-8-[³H]phenylxanthine. Proc.Natl.Acad.Sci.U.S.A. 77 5547 PMID: 6254090

Sigworth and Rea et al (2003) Adenosine A₁ receptors regulate the response of the mouse circadian clock to light. Brain Res. 960 246 PMID: 12505678

Asghari et al (2013) Adenosine A₁ receptor agonist, N⁶-cyclohexyladenosine, protects myelin and induces remyelination in an experimental model of rat optic chiasm demyelination; electrophysiological and histopathological studies. J.Neurol.Sci. 325 22 PMID: 23260322

Shao et al (2017) Adenosine A₁ receptor activation increases myocardial protein S-nitrosothiols and elicits protection from ischemia-reperfusion injury in male and female hearts. PLoS One 12 e0177315 PMID: 28493997

Futatsuki et al (2018) Involvement of orexin neurons in fasting- and central adenosine-induced hypothermia. Sci.Rep. 8 2717 PMID: 29426934

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关键词: N6-Cyclohexyladenosine, N6-Cyclohexyladenosine supplier, high, affinity, adenosine, A1, agonists, agonism, Adenosine, Receptors, 6863, Tocris Bioscience

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