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NAD 299 hydrochloride

Cat. No. 3282 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective, high affinity 5-HT1A antagonist
化学名： (3R)-3-(Dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NAD 299 hydrochloride

NAD 299 hydrochloride is a selective, high affinity 5-HT1A receptor antagonist (Ki = 0.6 nM in vitro). Enhances the action of selective 5-HT reuptake inhibitors and reverses citalopram-induced (Cat. No. 1427) inhibition of serotonergic cell firing.

许可信息

Sold for research purposes under agreement from AstraZeneca

化合物库 for NAD 299 hydrochloride

NAD 299 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for NAD 299 hydrochloride

分子量 354.85
公式 C18H23FN2O2.HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 184674-99-5
PubChem ID 90488823
InChI Key GSZJANKLCPHEEX-BTQNPOSSSA-N
Smiles FC1=C2C(C[C@@H](N(C4CCC4)C3CCC3)CO2)=C(C(N)=O)C=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NAD 299 hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 35.48 100
DMSO 35.48 100

制备储备液 for NAD 299 hydrochloride

以下数据基于产品分子量 354.85。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.09 mL 28.18 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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产品说明书 for NAD 299 hydrochloride

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for NAD 299 hydrochloride

参考文献是支持产品生物活性的出版物。

Larsson et al (1998) Differential regional antagonism of 8-OH-DPAT-induced decrease in serotonin synthesis by two 5-HT1A receptor antagonists. Eur.J.Pharmacol. 346 209 PMID: 9652362

Arborelius et al (1999) The 5-HT1A receptor antagonist robalzotan completely reverses citalopram-induced inhibition of serotonergic cell firing. Eur.J.Pharmacol. 382 133 PMID: 10528148

Johansson et al (1997) The pharmacological characterization of a novel selective 5-hydroxytryptamine-1A receptor antagonist, NAD-299. J.Pharmacol.Exp.Ther. 283 216 PMID: 9336327

If you know of a relevant reference for NAD 299 hydrochloride, please let us know.

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关键词: NAD 299 hydrochloride, NAD 299 hydrochloride supplier, AstraZeneca, 5-HT1A, serotonin, 5-HT, receptor, antagonists, NAD299, Receptors, 3282, Tocris Bioscience

1 篇 NAD 299 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NAD 299 hydrochloride 的部分引用包括：

Afshar et al (2019) Protective effects of 5-HT1A receptor antagonist and 5-HT2A receptor agonist on the biochemical and histological features in a rat model of Alzheimer's disease. J.Chem.Neuroanat. 96 140

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