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Submit ReviewNAV 26
Discontinued Product
4691 has been discontinued.
View all Voltage-gated Sodium (Na<sub>V</sub>) Channels products.
说明： Selective Nav1.7 channel blocker
化学名： 2,3-Dihydro-3-oxo-2-(tetrahydro-2H-pyran-4-yl)-N-[[4-(trifluoromethoxy)phenyl]methyl]-1H-isoindole-1-carboxamide
纯度： ≥98% (HPLC)
生物活性 for NAV 26
NAV 26 is a selective Nav1.7 channel blocker (IC50 = 370 nM). Exhibits >85-fold selectivity for Nav1.7 over Nav1.5 and hERG channels. Reduces nociceptive behavior in rat models of pain.
化合物库 for NAV 26
NAV 26 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for NAV 26
| 分子量 | 434.41 |
| 公式 | C22H21F3N2O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1198160-14-3 |
| PubChem ID | 44540282 |
| InChI Key | ICGMZCVSHDKQTE-UHFFFAOYSA-N |
| Smiles | O=C2C1=CC=CC=C1C(C(NCC4=CC=C(OC(F)(F)F)C=C4)=O)N2C3CCOCC3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NAV 26
参考文献 for NAV 26
参考文献是支持产品生物活性的出版物。
Macsari et al (2012) 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models. J.Med.Chem. 55 6866 PMID: 22770500
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关键词: NAV 26, NAV 26 supplier, NAV26, selective, NAv1.7, ion, channels, blockers, Voltage-gated, Sodium, Channels, 4691, Tocris Bioscience
1 篇 NAV 26 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NAV 26 的部分引用包括：
Dandan et al (2017) Regulatory role of tumor necrosis factor receptor-associated factor 6 in breast cancer by activating the protein kinase B/glycogen synthase kinase 3β signaling pathway. Mol Med Rep 16 2269-2273 PMID: 28627683
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