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NBD-PE

Cat. No. 7538 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Green-fluorescent label for lysosomal lipid bodies. Used for: Application: confocal microscopy
化学名： Triethylammonium (R)-2,3-bis(palmitoyloxy)propyl(2-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)ethyl)phosphate
纯度： ≥95% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NBD-PE

Key information: NBD-PE is a fluorescent label for lysosomal lipid bodies.

Used for: quantitatively measure phospholipidosis, which is useful to screen drugs for SARS-CoV-2 repurposing. NBD-PE can also be used to label giant unilamellar vesicles (GUV).

Application: confocal microscopy, fluorescence recovery after photobleaching (FRAP).

Properties and Photophysical Data: It consists of a single tail (16:0) phospholipid derivative with an NBD fluorophore conjugated to the head group. Excitation and emission maxima (λ) are 463 nm and 536 nm, respectively, extinction coefficient = 22,000 M-1cm-1.

Optical Data for NBD-PE

Emission Color Green
λabs 463 nm
λem 536 nm
Extinction Coefficient (ε) 22000 M-1cm-1
Application Confocal Microscopy

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

Spectral Viewer

Spectral Viewer

技术数据 for NBD-PE

分子量 956.26
公式 C43H75N4O11P.C6H15N
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 178119-00-1
InChI Key LEJHDNAGUHKMLR-GKEJWYBXSA-N
Smiles CC[N+](CC)([H])CC.CCCCCCCCCCCCCCCC(OC[C@@H](OC(CCCCCCCCCCCCCCC)=O)COP([O-])(OCCNC1=CC=C(N(=O)=O)C2=NON=C12)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NBD-PE

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
methanol 0.48 0.5 超声处理

制备储备液 for NBD-PE

以下数据基于产品分子量 956.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.005 mM 209.15 mL 1045.74 mL 2091.48 mL
0.025 mM 41.83 mL 209.15 mL 418.3 mL
0.05 mM 20.91 mL 104.57 mL 209.15 mL
0.25 mM 4.18 mL 20.91 mL 41.83 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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参考文献 for NBD-PE

参考文献是支持产品生物活性的出版物。

Morelli et al (2006) Validation of an in vitroscreen for phospholipidosis using a high-content biology platform. Cell Biol.Toxicol. 22 15 PMID: 16463016

Gum et al (2001) Analysis of two matrix metalloproteinase inhibitors and their metabolites for induction of phospholipidosis in rat and human hepatocytes. Biochem.Pharmacol. 62 1661 PMID: 11755120

Li et al (2020) Programmed magnetic manipulation of vesicles into spatially coded prototissue architectures arrays. Nat.Commun. 11 232 PMID: 31932592

Tummino et al (2021) Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2. Science 373 541 PMID: 34326236

If you know of a relevant reference for NBD-PE, please let us know.

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关键词: NBD-PE, NBD-PE supplier, NBDPE, phospholipid, derivative, fluorescence, NBD, label, lysosomal, lipid, bodies, quantitative, quantification, phospholipidosis, giant, unilamellar, vesicles, GUV, drug, screening, SARS-Cov-2, Fluorescent, Lipid, Probes, and, Cell, Membrane, Stains, Lysosome, 7538, Tocris Bioscience

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Fluorescent Dyes and Probes Research Product Guide

Fluorescent Dyes and Probes Research Product Guide

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