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Submit ReviewNBQX
说明： Potent AMPA antagonist; more selective than CNQX (Cat. No. 0190)
化学名： 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide
纯度： ≥98% (HPLC)
生物活性 for NBQX
NBQX is a selective and competitive AMPA and kainate receptor antagonist (IC50 = 0.15 μM and 4.8 μM, respectively). NBQX blocks the antidepressant effects of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529), decreases mTOR and BDNF levels. NBQX is neuroprotective, anticonvulsant, antinociceptive and active in vivo.
NBQX disodium salt, a more water-soluble form of NBQX, also available.
许可信息
Sold with the permission of Novo Nordisk A/S
化合物库 for NBQX
NBQX is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for NBQX
| 分子量 | 336.28 |
| 公式 | C12H8N4O6S |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 118876-58-7 |
| PubChem ID | 3272524 |
| InChI Key | UQNAFPHGVPVTAL-UHFFFAOYSA-N |
| Smiles | NS(=O)(=O)C1=CC=CC2=C3NC(=O)C(=O)NC3=CC(=C12)[N+]([O-])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for NBQX
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 33.63 | 100 |
制备储备液 for NBQX
以下数据基于产品分子量 336.28。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.97 mL | 14.87 mL | 29.74 mL |
| 5 mM | 0.59 mL | 2.97 mL | 5.95 mL |
| 10 mM | 0.3 mL | 1.49 mL | 2.97 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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产品说明书 for NBQX
参考文献 for NBQX
参考文献是支持产品生物活性的出版物。
Gill et al (1992) The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (NBQX) in a rat focal ischaemia model. Brain Res. 580 35 PMID: 1504814
Namba et al (1994) Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy. Brain Res. 638 36 PMID: 8199874
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Zeman and Lodge (1992) Pharmacological characterization of non-NMDA subtypes of glutamate receptors in the neonatal rat hemisected spinal cord in vitro. Br.J.Pharmacol. 106 367 PMID: 1382781
Yoon et al (2005) Antinociceptive interactions between intrathecal gabapentin and MK801 or NBQX in rat formalin test. J.Korean Med.Sci. 20 307 PMID: 15832006
If you know of a relevant reference for NBQX, please let us know.
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关键词: NBQX, NBQX supplier, Potent, selective, competitive, AMPA, antagonists, Glutamate, Receptors, iGluR, Ionotropic, neuroprotective, anticonvulsant, 0373, Tocris Bioscience
180 篇 NBQX 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NBQX 的部分引用包括：
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Partial block of AMPARs.
By
Sergiy Sylantyev on 12/15/2020
分析类型： In Vitro
种属： Rat
细胞系/组织： Cerebellar granule cell
NBQX was used to block evoked AMPA-receptor response in outside-out membrane patches excised from hippocampal granule cells. 0.1 µM concentration caused an immediate partial block (see illustration). Highly specific and potent ligand, but requires long sonication to prepare 10 mM DMSO stock.Illustration: I - control AMPAR response at -60 mV cell membrane potential; II - control AMPAR response at +40 mV cell membrane potential; III - NBQX at -60 mV cell membrane potential; IV - NBQX at +40 mV cell membrane potential.
Inhibition of Synaptic Transmission in the VP.
By
Anonymous on 02/02/2020
分析类型： In Vivo
种属： Mouse
NBQX (5 mM)
an AMPA receptor antagonist.
By
Anonymous on 01/31/2018
分析类型： Ex Vivo
种属： Rat
It is AMPA receptor antagonist. we used it at 30uM to block AMPA receptor in rat brain slice.
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