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Submit ReviewNCH 51
说明： Histone deacetylase inhibitor
别名： PTACH
化学名： 2-Methylpropanethioic acid S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester
纯度： ≥98% (HPLC)
生物活性 for NCH 51
NCH 51 is a histone deacetylase (HDAC) inhibitor. Inhibits growth of various cancer cells in vitro (EC50 = 1.1 - 9.1 μM).
技术数据 for NCH 51
| 分子量 | 390.56 |
| 公式 | C20H26N2O2S2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 848354-66-5 |
| PubChem ID | 11395181 |
| InChI Key | MDYDGUOQFUQOGE-UHFFFAOYSA-N |
| Smiles | O=C(CCCCCCSC(C(C)C)=O)NC1=NC(C2=CC=CC=C2)=CS1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NCH 51
参考文献 for NCH 51
参考文献是支持产品生物活性的出版物。
Suzuki et al (2005) Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J.Med.Chem. 48 1019 PMID: 15715470
Sanda et al (2007) Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells. Leukemia 21 2344 PMID: 17690692
关键词: NCH 51, NCH 51 supplier, NCH51, HDACs, inhibitors, inhibits, histone, deacetylases, epigenetics, PTACH, Non-selective, Non-Selective, 3747, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.