Nelfinavir mesylate

Cat. No. 3766 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent HIV-1 protease inhibitor

别名： AG 1341

化学名： (3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2- hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide methanesulfonate

纯度： ≥98% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Nelfinavir mesylate

Nelfinavir mesylate is an orally active human immunodeficiency virus protease inhibitor. Potently inhibits HIV-1 protease (K_i = 2 nM) in vitro. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC₅₀ = 0.08 μM).

许可信息

Sold for research purposes under agreement from Pfizer Inc.

技术数据 for Nelfinavir mesylate

分子量	663.89
公式	C₃₂H₄₅N₃O₄S.CH₄O₃S
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	159989-65-8
PubChem ID	64142
InChI Key	NQHXCOAXSHGTIA-SKXNDZRYSA-N
Smiles	[H][C@]12CCCC[C@]([H])1C[C@@H]([C@@](NC(C)(C)C)=O)N(C[C@@H](O)[C@H](CSC3=CC=CC=C3)NC(C4=C(C)C(O)=CC=C4)=O)C2.CS(=O)(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Nelfinavir mesylate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	66.39	100
	ethanol	66.39	100

制备储备液 for Nelfinavir mesylate

以下数据基于产品分子量 663.89。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.51 mL	7.53 mL	15.06 mL
5 mM	0.3 mL	1.51 mL	3.01 mL
10 mM	0.15 mL	0.75 mL	1.51 mL
50 mM	0.03 mL	0.15 mL	0.3 mL

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产品说明书 for Nelfinavir mesylate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Nelfinavir mesylate

参考文献是支持产品生物活性的出版物。

Shetty et al (1996) Preclinical pharmacokinetics and distribution to tissue of AG1343, an inhibitor of human immunodeficiency virus type 1 protease. Antimicrob.Agents Chemother. 40 110 PMID: 8787890

Patick et al (1996) Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease. Antimicrob.Agents Chemother. 40 29 PMID: 8787874

Gills et al (2007) Nelfinavir, a lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy and apoptosis in vitro and in vivo. Clin.Cancer Res. 13 5183

Musarrat et al (2020) The anti-HIV drug nelfinavir mesylate (Viracept) is a potent inhibitor of cell fusion caused by the SARSCoV-2 spike (S) glycoprotein warranting further evaluation as an antiviral against COVID-19 infections. J.Med.Virol. 92 2087 PMID: 32374457

Ko et al (2021) Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. Viruses 13 PMID: 33918958

If you know of a relevant reference for Nelfinavir mesylate, please let us know.

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1 篇 Nelfinavir mesylate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Nelfinavir mesylate 的部分引用包括：

Vladimir et al (2020) The anti-HIV drug nelfinavir mesylate (Viracept) is a potent inhibitor of cell fusion caused by the SARSCoV-2 spike (S) glycoprotein warranting further evaluation as an antiviral against COVID-19 infections. J Med Virol 92 2087-2095 PMID: 32374457

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