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Submit ReviewNemonapride
说明： Highly potent D2-like antagonist; also 5-HT1A agonist
别名： YM 09151,YM 09151-2
化学名： cis-5-Chloro-2-methoxy-4-(methylamino)-N-[2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]benzamide
纯度： ≥99% (HPLC)
生物活性 for Nemonapride
Nemonapride is a highly potent dopamine D2-like receptor antagonist; selective over D1-like receptors (Ki values are 0.1 and 740 nM for D2-like and D1-like receptors respectively). Also potent 5-HT1A receptor agonist (IC50 = 34 nM) and has affinity for sigma receptors.
化合物库 for Nemonapride
Nemonapride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for Nemonapride
| 分子量 | 387.91 |
| 公式 | C21H26ClN3O2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 75272-39-8 |
| PubChem ID | 76968489 |
| InChI Key | QCYCDKUNJFKYEI-ZVWWNKPMSA-N |
| Smiles | O=C(C3=C(OC)C=C(NC)C(Cl)=C3)N[C@@H]1CCN(CC2=CC=CC=C2)[C@@H]1C.O=C(C6=C(OC)C=C(NC)C(Cl)=C6)N[C@H]4CCN(CC5=CC=CC=C5)[C@H]4C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Nemonapride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| ethanol | 7.76 | 20 | |
| DMSO | 9.7 | 25 |
制备储备液 for Nemonapride
以下数据基于产品分子量 387.91。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 10.31 mL | 51.56 mL | 103.12 mL |
| 1.25 mM | 2.06 mL | 10.31 mL | 20.62 mL |
| 2.5 mM | 1.03 mL | 5.16 mL | 10.31 mL |
| 12.5 mM | 0.21 mL | 1.03 mL | 2.06 mL |
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产品说明书 for Nemonapride
参考文献 for Nemonapride
参考文献是支持产品生物活性的出版物。
Assie et al (1997) 5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and cloz. Eur.J.Pharmacol. 334 141 PMID: 9369342
Terai et al (1983) Selective binding of YM-09151-2, a new potent neuroleptic, to D2-DArgic receptors. Jpn.J.Pharmacol. 33 749 PMID: 6138453
Ujike et al (1996) [3H]YM-09151-2 (nemonapride), a potent radioligand for both sigma1 and sigma2 receptor subtypes. Neuroreport 7 1057 PMID: 8804051
If you know of a relevant reference for Nemonapride, please let us know.
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关键词: Nemonapride, Nemonapride supplier, 5-HT1A, agonists, potent, D2-like, dopamine, antagonists, Serotonin, Receptors, Non-Selective, dopaminergic, YM09151, YM09151-2, YM, 09151, 09151-2, Non-selective, Dopamine, 1746, Tocris Bioscience
1 篇 Nemonapride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Nemonapride 的部分引用包括：
Gadgaard & Jensen (2020) Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay Biochem Pharmacol 175 PMID: 32088264
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.