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Submit ReviewNeuropeptide AF (human) is an endogenous antiopioid neuropeptide and agonist at NPFF1 and NPFF2 receptors. Implicated in pain modulation and endocrine functions. May also regulate metabolism via stimulation of β-adrenoceptor expression in adipocytes. Also MRGPRA agonist
分子量 | 1978.19 |
公式 | C90H132N26O25 |
序列 |
AGEGLNSQFWSLAAPQRF (Modifications: Phe-18 = C-terminal amide) |
储存 | Desiccate at -20°C |
CAS Number | 192387-38-5 |
PubChem ID | 90488726 |
InChI Key | DYSIROANKWMSGC-KWFINLGMSA-N |
Smiles | [H]N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
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Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Elshourbagy et al (2000) Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor. J.Biol.Chem. 275 25965 PMID: 10851242
Lefrere et al (2002) Neuropeptide AF and FF modulation of adipocyte metabolism. J.Biol.Chem. 277 39169 PMID: 12149260
Vilim et al (1999) Gene for pain modulatory neuropeptide FF: induction in spinal cord by noxious stimuli. Mol.Pharmacol. 55 804 PMID: 10220558
Solinski et al (2014) Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 66 570 PMID: 24867890
关键词: Neuropeptide AF (human), Neuropeptide AF (human) supplier, Implicated, pain, modulation, antiopioid, neuropeptides, FF, AF, NPFF, Receptors, NPFF1, NPFF2, endogenous, agonists, MRGPRA, mas-related, gene, protein, coupled, agonism, NPAF, Neuropeptide, (human, FMRFamide-related), Miscellaneous/Non-selective, Opioids, FF/AF, Mas-related, G, Protein-Coupled, 1928, Tocris Bioscience
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