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Submit ReviewNeuropeptide FF
说明： Endogenous NPFF1 and NPFF2 agonist; also MRGPRA agonist
纯度： ≥95% (HPLC)
生物活性 for Neuropeptide FF
Neuropeptide FF is an endogenous antiopioid peptide and agonist at NPFF1 and NPFF2 receptors (Ki values are 2.82 and 0.21 nM respectively). Exhibits anorexigenic effects following i.c.v. administration. Also MRGPRA agonist.
技术数据 for Neuropeptide FF
| 分子量 | 1081.28 |
| 公式 | C54H76N14O10 |
| 序列 |
FLFQPQRF (Modifications: Phe-8 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 99566-27-5 |
| PubChem ID | 9854861 |
| InChI Key | HWYCFZUSOBOBIN-AQJXLSMYSA-N |
| Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Neuropeptide FF
| 溶解性 | Soluble to 0.50 mg/ml in water |
产品说明书 for Neuropeptide FF
参考文献 for Neuropeptide FF
参考文献是支持产品生物活性的出版物。
Cline et al (2007) Central neuropeptide FF reduces feed consumption and affects hypothalamic chemistry in chicks. Neuropeptides 41 433 PMID: 17936900
Gouarderes et al (2007) Functional differences between NPFF1 and NPFF2 receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of[35S]GTPγS binding. Neuropharmacology 52 376 PMID: 17011599
Solinski et al (2014) Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 66 570 PMID: 24867890
If you know of a relevant reference for Neuropeptide FF, please let us know.
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关键词: Neuropeptide FF, Neuropeptide FF supplier, Endogenous, NPFF1, NPFF2, agonists, Anti-opioids, NPFFR1, NPFFR2, Receptors, Neuropeptides, FF/AF, NeuropeptideFF, MRGPRA, mas-related, g, protein-coupled, agonism, Miscellaneous/Non-selective, Opioids, Neuropeptide, Mas-related, G, Protein-Coupled, 3137, Tocris Bioscience
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