NFAT inhibitor, Cell Permeable

Pricing Availability   Qty
说明: Cell permeable NFAT inhibitor
别名: 11R-VIVIT
纯度: ≥95% (HPLC)
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引用文献
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生物活性 for NFAT inhibitor, Cell Permeable

NFAT inhibitor, Cell Permeable is an NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Reduces inflammation and epithelial damage in a mouse model of colitis. In an animal model of Alzheimer's disease NFAT inhibitor improves cognitive and synaptic function, reduces glial activation and lowers amyloid levels; in vitro it reduces glutamate dysregulation and neuron hyperactivity.

技术数据 for NFAT inhibitor, Cell Permeable

分子量 3573.15
公式 C147H259N67O36S
序列 RRRRRRRRRRRGGGMAGPHPVIVITGPHEE
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 592517-80-1
PubChem ID 16140839
InChI Key VNTCWMOQGXMIQP-PIQGMSCVSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NFAT inhibitor, Cell Permeable

溶解性 Soluble to 1 mg/ml in water

产品说明书 for NFAT inhibitor, Cell Permeable

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参考文献 for NFAT inhibitor, Cell Permeable

参考文献是支持产品生物活性的出版物。

Elloumi et al (2012) A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis. PLoS One 7 e34172 PMID: 22479554

Noguchi et al (2004) A new cell-permeable peptide allows successful allogeneic islet transplantation in mice. Nat.Med. 10 305 PMID: 14770176

Lee et al (2022) Function and therapeutic value of astrocytes in neurological diseases. Nat.Rev.Drug Discov. 21 339 PMID: 35173313

Elloumi et al (2012) A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis. PLoS One 7 e34172 PMID: 22479554

Sompol et al (2017) Calcineurin/NFAT signaling in activated astrocytes drives network hyperexcitability in Aβ-bearing mice. J.Neurosci. 37 6132 PMID: 28559377


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关键词: NFAT inhibitor, Cell Permeable, NFAT inhibitor, Cell Permeable supplier, NFAT, inhibitors, inhibits, nuclear, factor, of, activated, T, cells, interleukin, IL-12, IL-23, TNF, anti-inflammatory, inflammation, colitis, 11R-VIVIT, amyloid, Alzheimers, glutamate, neurons, immune, suppression, 5710, Tocris Bioscience

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To determine the effects of a cell permeable NFAT inhibitor in IC-21 cell line.
By Meghan Bradshaw on 02/20/2019
种属: Human
细胞系/组织: IC-21 cell line

NFAT function in macrophages and we worked to determine the effects of a cell permeable NFAT inhibitor in IC-21 cell line.

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